| Phillies | 4 | Mets | 0 | Final |
| 16:40 | Nationals | Trevor Williams | 4-0 1.96 | @ | White Sox | Chris Flexen | 2-3 4.29 | ||
| 18:35 | Blue Jays | Chris Bassitt | 3-5 5.06 | @ | Orioles | Kyle Bradish | 0-0 1.86 | ||
| 18:40 | Marlins | Ryan Weathers | 2-4 4.54 | @ | Tigers | Reese Olson | 0-4 2.52 | ||
| 19:10 | Rays | Aaron Civale | 2-3 5.88 | @ | Red Sox | Nick Pivetta | 1-2 3.60 | ||
| 19:20 | Cubs | Jameson Taillon | 4-0 0.90 | @ | Braves | Chris Sale | 5-1 2.95 | ||
| 19:40 | Yankees | Carlos Rodón | 3-2 3.56 | @ | Twins | Chris Paddack | 4-1 4.34 | ||
| 19:40 | Pirates | Quinn Priester | 0-3 3.86 | @ | Brewers | Joe Ross | 1-4 4.75 | ||
| TBD | Nationals | Mitchell Parker | 2-1 2.67 | @ | White Sox | Erick Fedde | 3-0 3.65 | ||
| 20:05 | Guardians | Ben Lively | 2-2 2.43 | @ | Rangers | Jack Leiter | 0-0 12.91 | ||
| 20:10 | Athletics | JP Sears | 3-2 4.20 | @ | Astros | Ronel Blanco | 4-0 2.23 | ||
| 21:38 | Cardinals | Sonny Gray | 4-2 2.29 | @ | Angels | Reid Detmers | 3-5 5.65 | ||
| 21:40 | Reds | Hunter Greene | 1-2 3.38 | @ | Diamondbacks | Slade Cecconi | 1-2 4.15 | ||
| 21:40 | Rockies | Cal Quantrill | 2-3 3.94 | @ | Padres | Dylan Cease | 5-2 2.19 | ||
| 21:40 | Royals | Michael Wacha | 2-5 6.08 | @ | Mariners | Logan Gilbert | 4-1 2.55 | ||
| 21:45 | Dodgers | Gavin Stone | 3-1 3.55 | @ | Giants | Keaton Winn | 3-6 6.69 |