| 8:40 | Giants | Jordan Hicks | 2-1 1.89 | @ | Rockies | Cal Quantrill | 1-3 4.31 | ||
| 12:35 | Angels | José Soriano | 1-4 3.77 | @ | Pirates | Martín Pérez | 1-2 3.15 | ||
| 13:05 | Blue Jays | Yariel Rodríguez | 0-1 4.11 | @ | Phillies | Spencer Turnbull | 2-0 1.31 | ||
| 13:10 | Tigers | Reese Olson | 0-4 2.70 | @ | Guardians | Tanner Bibee | 2-1 4.46 | ||
| 13:15 | Mets | Adrian Houser | 0-3 8.16 | @ | Cardinals | Steven Matz | 1-2 6.18 | ||
| 14:10 | Brewers | Joe Ross | 1-3 4.65 | @ | Royals | Brady Singer | 2-1 2.45 | ||
| 14:20 | Padres | Joe Musgrove | 3-3 6.37 | @ | Cubs | Ben Brown | 0-1 4.23 | ||
| 15:10 | Marlins | Ryan Weathers | 2-3 4.54 | @ | Dodgers | Gavin Stone | 2-1 4.06 | ||
| 15:37 | Rangers | Nathan Eovaldi | 2-2 2.61 | @ | Athletics | JP Sears | 2-2 3.89 | ||
| 18:40 | Diamondbacks | Jordan Montgomery | 1-2 5.62 | @ | Reds | Nick Martinez | 0-2 4.78 | ||
| 18:45 | Orioles | Grayson Rodriguez | 4-1 3.71 | @ | Nationals | Mitchell Parker | 2-1 2.53 | ||
| 18:50 | White Sox | Brad Keller | 0-1 3.86 | @ | Rays | Aaron Civale | 2-2 6.14 | ||
| 19:05 | Astros | Spencer Arrighetti | 0-3 8.27 | @ | Yankees | Carlos Rodón | 2-2 3.68 | ||
| 19:20 | Red Sox | Josh Winckowski | 1-1 3.47 | @ | Braves | Chris Sale | 4-1 3.44 | ||
| 19:40 | Mariners | George Kirby | 3-2 3.76 | @ | Twins | Chris Paddack | 3-1 4.78 | ||
| TBD | Rangers | Michael Lorenzen | 2-1 3.52 | @ | Athletics | TBD |