| 13:05 | Twins | Simeon Woods Richardson | 2-0 2.70 | @ | Astros | Hunter Brown | 1-5 6.39 | ||
| 13:35 | Rays | Zack Littell | 2-3 3.03 | @ | Orioles | Cole Irvin | 5-2 2.84 | ||
| 13:35 | Athletics | Luis Medina | 0-0 0.00 | @ | Braves | Charlie Morton | 3-2 4.29 | ||
| 13:35 | Tigers | Casey Mize | 1-3 4.71 | @ | Red Sox | Brayan Bello | 6-2 4.18 | ||
| 13:37 | Pirates | Quinn Priester | 0-4 4.33 | @ | Blue Jays | Chris Bassitt | 5-6 4.03 | ||
| 13:40 | Rangers | Andrew Heaney | 1-6 4.47 | @ | Marlins | Trevor Rogers | 1-6 5.65 | ||
| 13:40 | Nationals | Jake Irvin | 2-5 3.43 | @ | Guardians | Carlos Carrasco | 2-4 5.16 | ||
| 13:40 | Diamondbacks | Brandon Pfaadt | 2-4 4.16 | @ | Mets | Jose Quintana | 1-5 5.06 | ||
| 14:10 | White Sox | Nick Nastrini | 0-4 9.92 | @ | Brewers | Freddy Peralta | 3-3 3.61 | ||
| 14:10 | Padres | Michael King | 4-4 4.09 | @ | Royals | Cole Ragans | 4-4 3.49 | ||
| 14:20 | Reds | Nick Lodolo | 4-2 3.12 | @ | Cubs | Ben Brown | 1-1 2.72 | ||
| 16:05 | Yankees | Nestor Cortes | 3-4 3.30 | @ | Giants | Blake Snell | 0-3 10.42 | ||
| 16:10 | Angels | Griffin Canning | 2-4 5.08 | @ | Mariners | Luis Castillo | 4-6 3.41 | ||
| 16:10 | Rockies | Austin Gomber | 1-2 2.76 | @ | Dodgers | Gavin Stone | 5-2 3.16 | ||
| 19:10 | Cardinals | Lance Lynn | 2-3 3.45 | @ | Phillies | Taijuan Walker | 3-1 5.51 |