| Date | Status | Player | Injury | Target Return? | Prognosis |
|---|
| 2022-10-08 | 60-day | Jacob Amaya | Undisclosed | 2022-12-07 | The Los Angeles Dodgers placed INF Jacob Amaya on the 60-day injured list. |
| 2022-10-01 | 60-day | Emmanuel Rivera | Wrist | 2022-11-30 | The Arizona Diamondbacks placed INF Emmanuel Rivera on the 60-day injured list. |
| 2022-09-30 | 60-day | Zack Britton | Shoulder | 2022-11-29 | The New York Yankees placed LHP Zack Britton on the 60-day injured list with left shoulder fatigue. |
| 2022-09-28 | 60-day | Huascar Ynoa | Undisclosed | 2022-11-27 | The Atlanta Braves placed RHP Huascar Ynoa on the 60-day injured list. |
| 2022-09-28 | 60-day | Matt Manning | Forearm | 2022-11-27 | The Detroit Tigers placed RHP Matt Manning on the 60-day injured list. |
| 2022-09-27 | 60-day | Sandy León | Knee | 2022-11-26 | The Minnesota Twins placed C Sandy León on the 60-day injured list. |
| 2022-09-25 | 60-day | Art Warren | Elbow | 2022-11-24 | The Cincinnati Reds placed RHP Art Warren on the 60-day injured list. |
| 2022-09-21 | 60-day | Nick Anderson | Foot | 2022-11-20 | The Tampa Bay Rays placed RHP Nick Anderson on the 60-day injured list due to plantar fasciitis. |
| 2022-09-20 | 60-day | Nick Senzel | Toe | 2022-11-19 | The Cincinnati Reds transferred OF Nick Senzel from the 10-day injured list to the 60-day injured list with a left sesmoid fracture. |
| 2022-09-14 | 60-day | Nick Solak | Foot | 2022-11-13 | The Texas Rangers placed OF Nick Solak on the 60-day injured list with a right foot fracture. |
| 2022-09-14 | 60-day | Kent Emanuel | Shoulder | 2022-11-13 | The Philadelphia Phillies placed LHP Kent Emanuel on the 60-day injured list. |
| 2022-09-13 | 60-day | Andrew Velazquez | Foot | 2022-11-12 | The Los Angeles Angels transferred INF Andrew Velazquez to the 60-day injured list. |
| 2022-09-13 | 60-day | Rafael Ortega | Finger | 2022-11-12 | The Chicago Cubs placed OF Rafael Ortega on the 60-day injured list with a left ring finger fracture. |
| 2022-09-12 | 60-day | Mark Appel | Elbow | 2022-11-11 | The Philadelphia Phillies placed RHP Mark Appel on the 60-day injured list with right elbow inflammation. |
| 2022-09-12 | 60-day | Brandon Lowe | Back | 2022-11-11 | The Tampa Bay Rays placed INF Brandon Lowe on the 60-day injured list. |
| 2022-09-10 | 60-day | Brendan McKay | Elbow | 2022-11-09 | The Tampa Bay Rays placed LHP Brendan McKay on the 60-day injured list. |
| 2022-09-09 | 60-day | Brad Miller | Hip | 2022-11-08 | The Texas Rangers placed INF Brad Miller on the 60-day injured list. |
| 2022-09-05 | 60-day | Franchy Cordero | Ankle | 2022-11-13 | The Boston Red Sox placed INF Franchy Cordero on the 60-day injured list. |
| 2022-09-04 | 60-day | Jhonathan Díaz | Undisclosed | 2022-11-13 | The Los Angeles Angels placed LHP Jhonathan Diaz on the 60-day injured list. |
| 2022-09-03 | 60-day | Alex Wood | Shoulder | 2022-11-13 | The San Francisco Giants placed LHP Alex Wood on the 60-day injured list with a left shoulder impingement. |
| 2022-08-30 | 60-day | Josh Sborz | Elbow | 2022-11-13 | The Texas Rangers placed RHP Josh Sborz on the 60-day injured list with a right elbow sprain. |
| 2022-08-28 | 60-day | Luis Gil | Elbow | 2022-11-13 | The New York Yankees placed RHP Luis Gil from on the 60-day injured list. |
| 2022-08-27 | 60-day | Dany Jiménez | Shoulder | 2022-11-13 | The Oakland Athletics placed RHP Dany Jiménez on the 60-day injured list with a right shoulder strain. |
| 2022-08-27 | 60-day | Ryan Thompson | Triceps | 2022-11-13 | The Tampa Bay Rays placed RHP Ryan Thompson on the 60-day injured list. |
| 2022-08-26 | 60-day | Sam Long | Oblique | 2022-11-13 | The San Francisco Giants placed LHP Sam Long on the 60-day injured list with an oblique strain. |
| 2022-08-26 | 60-day | Símon Muzziotti | Knee | 2022-11-13 | The Philadelphia Phillies placed OF Simon Muzziotti on the 60-day injured list with a torn patellar tendon in his right knee. |
| 2022-08-25 | 60-day | Jared Walsh | Rib | 2022-11-13 | The Los Angeles Angels placed INF Jared Walsh on the 60-day injured list. |
| 2022-08-24 | 60-day | Colin Holderman | Shoulder | 2022-11-13 | The Pittsburgh Pirates placed RHP Colin Holderman on the 60-day injured list. |
| 2022-08-23 | 60-day | Brandon Belt | Knee | 2022-11-13 | The San Francisco Giants placed INF Brandon Belt on the 60-day injured list. |
| 2022-08-23 | 60-day | Gregory Santos | Groin | 2022-11-13 | The San Francisco Giants placed RHP Gregory Santos on the 60-day Injured List. |
| 2022-08-23 | 60-day | Mike Moustakas | Calf | 2022-11-13 | The Cincinnati Reds placed INF Mike Moustakas on the 60-day injured list. |
| 2022-08-21 | 60-day | Donovan Walton | Shoulder | 2022-11-13 | The San Francisco Giants placed INF Donovan Walton on the 60-day injured list. |
| 2022-08-20 | 60-day | Yadiel Hernandez | Calf | 2022-11-13 | The Washington Nationals placed OF Yadiel Hernandez on the 60-day injured list. |
| 2022-08-19 | 60-day | Joey Votto | Rotator Cuff | 2022-11-13 | The Cincinnati Reds placed INF Joey Votto on the 60-day injured list. |
| 2022-08-14 | 60-day | Corey Knebel | Lat | 2022-11-13 | The Philadelphia Phillies placed RHP Corey Knebel on the 60-day injured list. |
| 2022-08-13 | 60-day | Anthony Bender | Elbow | 2022-11-13 | The Miami Marlins transferred RHP Anthony Bender to the 60-day injured list. |
| 2022-08-12 | 60-day | Yerry De Los Santos | Lat | 2022-11-13 | The Pittsburgh Pirates placed RHP Yerry De Los Santos on the 60-day injured list. |
| 2022-08-10 | 60-day | Paul Blackburn | Finger | 2022-11-13 | The Oakland Athletics placed RHP Paul Blackburn on the 60-day injured list and will be shutdown for the remainder of the season. |
| 2022-08-09 | 60-day | Tanner Houck | Back | 2022-11-13 | The Boston Red Sox placed RHP Tanner Houck on the 60-day injured list. |
| 2022-08-02 | 60-day | Alex Kirilloff | Wrist | 2022-11-13 | The Minnesota Twins transferred OF/IF Alex Kirilloff to the 60-day injured list. |
| 2022-08-01 | 60-day | Tarik Skubal | Arm | 2022-11-13 | The Detroit Tigers transferred LHP Tarik Skubal to the 60-day injured list. |
| 2022-07-30 | 60-day | Miguel Sanó | Knee | 2022-11-13 | The Minnesota Twins placed INF Miguel Sanó on the 60-day injured list. |
| 2022-07-29 | 60-day | Tyler Gilbert | Elbow | 2022-11-13 | The Arizona Diamondbacks placed LHP Tyler Gilbert on the 60-day injured list. |
| 2022-07-28 | 60-day | Jordan Holloway | Elbow | 2022-11-13 | The Miami Marlins placed RHP Jordan Holloway on the 60-day injured list. |
| 2022-07-26 | 60-day | Angel Zerpa | Knee | 2022-11-13 | The Kansas City Royals placed LHP Angel Zerpa on the 60-day injured list. |
| 2022-07-24 | 60-day | Rony García | Bicep | 2022-11-13 | The Detroit Tigers placed RHP Rony GarcÃa on the 60-day injured list. |
| 2022-07-24 | 60-day | Jeff Hoffman | Forearm | 2022-11-13 | The Cincinnati Reds placed RHP Jeff Hoffman on the 60-day injured list. |
| 2022-07-23 | 60-day | Michael King | Elbow | 2022-11-13 | The New York Yankees placed RHP Michael King on the 60-day injured list with a right elbow fracture. |
| 2022-07-23 | 60-day | Adam Duvall | Wrist | 2022-11-13 | The Atlanta Braves placed OF Adam Duvall on the 60-day injured list. |
| 2022-07-23 | 60-day | Max Meyer | Elbow | 2022-11-13 | The Miami Marlins placed RHP Max Meyer on the 60-day injured list. |
| 2022-07-23 | 60-day | Jorge Soler | Back | 2022-11-13 | The Miami Marlins placed OF Jorge Soler on the 60-day injured list. |
| 2022-07-22 | 60-day | Tyler Stephenson | Clavicle | 2022-11-13 | The Cincinnati Reds placed C Tyler Stephenson on the 60-day injured list with a broken right clavicle. |
| 2022-07-19 | 60-day | Cody Poteet | Elbow | 2022-11-13 | The Miami Marlins placed RHP Cody Poteet on the 60-day injured list. |
| 2022-07-18 | 60-day | Beau Brieske | Forearm | 2022-11-13 | The Detroit Tigers transferred RHP Beau Brieske to the 60-day injured list. |
| 2022-07-17 | 60-day | Chris Sale | Finger | 2022-11-13 | The Boston Red Sox placed LHP Chris Sale on the 60-day injured list. |
| 2022-07-16 | 60-day | Mauricio Llovera | Hip | 2022-11-13 | The San Francisco Giants placed RHP Mauricio Llovera on the 60-day injured list with a right flexor strain. |
| 2022-07-15 | 60-day | Drew VerHagen | Hip | 2022-11-13 | The St. Louis Cardinals transferred RHP Drew VerHagen from the 15-day injured list to the 60-day injured list. |
| 2022-07-15 | 60-day | Hans Crouse | Biceps | 2022-11-13 | The Philadelphia Phillies placed RHP Hans Crouse on the 60-day injured list. |
| 2022-07-13 | 60-day | Tanner Rainey | Elbow | 2022-11-13 | The Washington Nationals placed RHP Tanner Rainey on the 60-day injured list with a right UCL sprain. |
| 2022-07-12 | 60-day | Darren O'Day | Calf | 2022-11-13 | The Atlanta Braves placed RHP Darren O'Day on the 60-day injured list. |
| 2022-07-11 | 60-day | Mitch Garver | Forearm | 2022-11-13 | The Texas Rangers placed C Mitch Garver on the 60-day injured list. |
| 2022-07-11 | 60-day | Shane Baz | Elbow | 2022-11-13 | The Tampa Bay Rays placed RHP Shane Baz on the 60-day injured list. |
| 2022-07-09 | 60-day | Kevin Kiermaier | Hip | 2022-11-13 | The Tampa Bay Rays placed OF Kevin Kiermaier on the 60-day injured list. |
| 2022-07-08 | 60-day | Colton Welker | Shoulder | 2022-11-13 | The San Francisco Giants placed INF Colton Welker on the 60-day injured list. |
| 2022-07-07 | 60-day | José Álvarez | Elbow | 2022-11-13 | The San Francisco Giants placed LHP José Ãlvarez on the 60-day injured list. |
| 2022-07-05 | 60-day | Kyle Hendricks | Shoulder | 2022-11-13 | The Chicago Cubs placed RHP Kyle Hendricks on the 60-day injured list. |
| 2022-07-04 | 60-day | Jackson Tetreault | Shoulder | 2022-11-13 | The Washington Nationals placed RHP Jackson Tetreault on the 60-day injured list. |
| 2022-07-03 | 60-day | Anthony Gose | Triceps | 2022-11-13 | The Cleveland Guardians placed LHP Anthony Gose on the 60-day injured list with a left tricep strain. |
| 2022-07-02 | 60-day | Alec Mills | Back | 2022-11-13 | The Chicago Cubs placed RHP Alec Mills on the 60-day injured list. |
| 2022-07-01 | 60-day | Jason Castro | Knee | 2022-11-13 | The Houston Astros transferred C Jason Castro to the 60-day injured list. |
| 2022-07-01 | 60-day | Anthony DeSclafani | Ankle | 2022-11-13 | The San Francisco Giants placed RHP Anthony DeSclafani on the 60-day injured list. |
| 2022-06-30 | 60-day | Jason Heyward | Knee | 2022-11-13 | The Chicago Cubs placed OF Jason Heyward on the 60-day injured list. |
| 2022-06-29 | 60-day | James McArthur | Elbow | 2022-11-13 | The Philadelphia Phillies placed RHP James McArthur on the 60-day injured list. |
| 2022-06-28 | 60-day | Max Kranick | Elbow | 2022-11-13 | The Pittsburgh Pirates placed RHP Max Kranick on the 60-day injured list as he recovers from Tommy John surgery. |
| 2022-06-28 | 60-day | Jazz Chisholm Jr. | Back | 2022-11-13 | The Miami Marlins placed INF Jazz Chisholm Jr. on the 60-day injured list. |
| 2022-06-28 | 60-day | Austin Meadows | Mental Health | 2022-11-13 | The Detroit Tigers placed OF Austin Meadows on the 60-day injured list. |
| 2022-06-27 | 60-day | Damon Jones | Shoulder | 2022-11-13 | The Philadelphia Phillies placed LHP Damon Jones on the 60-day injured list. |
| 2022-06-26 | 60-day | Michael Brantley | Shoulder | 2022-11-13 | The Houston Astros transferred OF Michael Brantley to the 60-day injured list. |
| 2022-06-25 | 60-day | Daniel Hudson | ACL | 2022-11-13 | The Los Angeles Dodgers placed RHP Daniel Hudson on the 60-day injured list with a torn ACL. |
| 2022-06-25 | 60-day | Trevor Larnach | Core | 2022-11-13 | The Minnesota Twins placed OF Trevor Larnach on the 60-day injured list. |
| 2022-06-23 | 60-day | Josh James | Lat | 2022-11-13 | The Houston Astros placed RHP Josh James on the 60-day injured list with a right lat strain. |
| 2022-06-22 | 60-day | Danny Mendick | Knee | 2022-11-13 | The Chicago White Sox placed INF Danny Mendick on the 60-day injured list. |
| 2022-06-21 | 60-day | Sam Delaplane | Forearm | 2022-11-13 | The San Francisco Giants placed RHP Sam Delaplane on the 60-day injured list. |
| 2022-06-18 | 60-day | Evan Lee | Flexor | 2022-11-13 | The Washington Nationals transferred LHP Evan Lee to the 60-day injured list. |
| 2022-06-17 | 60-day | Canaan Smith-Njigba | Wrist | 2022-11-13 | The Pittsburgh Pirates placed OF Canaan Smith-Njigba on the 60-day injured list. |
| 2022-06-17 | 60-day | Tony Santillan | Back | 2022-11-13 | The Cincinnati Reds placed RHP Tony Santillan on the 60-day injured list. |
| 2022-06-14 | 15-day | Stephen Strasburg | Ribs | 2022-05-01 | The Washington Nationals placed RHP Stephen Strasburg on the 10-day injured list with a stress reaction of the ribs. |
| 2022-06-13 | 60-day | Eli White | Wrist | 2022-11-13 | The Texas Rangers placed OF Eli White on the 60-day injured list. |
| 2022-06-12 | 60-day | Tyler Kinley | Elbow | 2022-11-13 | The Colorado Rockies placed RHP Tyler Kinley on the 60-day injured list. |
| 2022-06-10 | 60-day | Walker Buehler | Elbow | 2022-11-13 | The Los Angeles Dodgers placed RHP Walker Buehler on the 60-day injured list. |
| 2022-06-10 | 60-day | Alex Jackson | Wrist | 2022-11-13 | The Milwaukee Brewers placed C Alex Jackson on the 60-day injured list with left wrist inflammation. |
| 2022-06-10 | 60-day | Mike Zunino | Shoulder | 2022-11-13 | The Tampa Bay Rays placed C Mike Zunino on the 60-day injured list with left shoulder inflammation. |
| 2022-06-08 | 60-day | Andrew Kittredge | Elbow | 2022-11-13 | The Tampa Bay Rays placed RHP Andrew Kittredge on the 60-day injured list. |
| 2022-06-04 | 60-day | Vladimir Gutierrez | Forearm | 2022-11-13 | The Cincinnati Reds placed RHP Vladimir Gutierrez on the 60-day injured list. |
| 2022-06-03 | 60-day | J.P. Feyereisen | Shoulder | 2022-11-13 | The Tampa Bay Rays transferred RHP J.P. Feyereisen from the 15-day injured list to the 60-day injured list with a right shoulder impingement. |
| 2022-06-02 | 60-day | Kevin Pillar | Shoulder | 2022-11-13 | The Los Angeles Dodgers placed OF Kevin Pillar on the 60-day injured list with a left shoulder fracture. |
| 2022-06-01 | 60-day | Humberto Castellanos | Elbow | 2022-11-13 | The Arizona Diamondbacks placed RHP Humberto Castellanos on the 60-day injured list. |
| 2022-06-01 | 60-day | Hyun Jin Ryu | Forearm | 2022-11-13 | The Toronto Blue Jays placed LHP Hyun Jin Ryu on the 60-day injured list with left forearm inflammation. |
| 2022-05-29 | 60-day | Royce Lewis | Knee | 2022-11-13 | The Minnesota Twins placed INF Royce Lewis on the 60-day injured list. |
| 2022-05-28 | 60-day | Helcris Olivarez | Shoulder | 2022-11-13 | The Colorado Rockies placed LHP Helcris Olivarez on the 60-day injured list with a shoulder strain. |
| 2022-05-22 | 60-day | Cody Stashak | Shoulder | 2022-11-13 | The Minnesota Twins placed RHP Cody Stashak on the 60-day injured list. |
| 2022-05-20 | 60-day | Daulton Jefferies | Arm | 2022-11-13 | The Oakland Athletics placed RHP Daulton Jeffries on the 60-day injured list. |
| 2022-05-19 | 60-day | Chad Green | Elbow | 2022-11-13 | The New York Yankees placed RHP Chad Green on the 60-day injured list. |
| 2022-05-16 | 60-day | Nick Ahmed | Shoulder | 2022-11-13 | The Arizona Diamondbacks placed INF Nick Ahmed on the 60-day injured list with right shoulder inflammation. |
| 2022-05-11 | 60-day | Lucas Sims | Back | 2022-11-13 | The Cincinnati Reds placed RHP Lucas Sims on the 60-day injured list. He's expected to miss the rest of the season. |
| 2022-05-09 | 60-day | Chris Paddack | Elbow | 2022-11-13 | The Twins placed RHP Chris Paddack on the 60-day injured list. |
| 2022-05-07 | 60-day | Roberto Pérez | Hamstring | 2022-11-13 | The Pittsburgh Pirates placed C Roberto Pérez on the 60-day injured list. |
| 2022-05-06 | 60-day | Tom Murphy | Shoulder | 2022-11-13 | The Seattle Mariners placed C Tom Murphy on the 60-day injured list. |
| 2022-04-30 | 60-day | Jake Brentz | Flexor | 2022-11-13 | The Kansas City Royals transferred LHP Jake Brentz from the 10-day injured list to the 60-day injured list with a left flexor strain. |
| 2022-04-30 | 60-day | Ethan Roberts | Shoulder | 2022-11-13 | The Chicago Cubs placed RHP Ethan Roberts on the 60-day injured list. |
| 2022-04-30 | 60-day | Sean Reid-Foley | Elbow | 2022-11-13 | The New York Mets placed RHP Sean Reid-Foley on the 60-day injured list. |
| 2022-04-29 | 60-day | Tayler Saucedo | Hip | 2022-11-13 | The Toronto Blue Jays placed LHP Tayler Saucedo on the 60-day injured list. |
| 2022-04-28 | 60-day | Manny Piña | Wrist | 2022-11-13 | The Atlanta Braves placed C Manny Piña on the 10-day injured list. |
| 2022-04-26 | 60-day | Adalberto Mondesi | Knee | 2022-11-13 | The Kansas City Royals placed INF Adalberto Mondesi on the 60-day injured list. |
| 2022-04-24 | 60-day | Justin Wilson | Elbow | 2022-11-13 | The Cincinnati Reds placed LHP Justin Wilson on the 60-day injured list. |
| 2022-04-20 | 60-day | Sean Doolittle | Elbow | 2022-11-13 | The Washington Nationals placed LHP Sean Doolittle on the 60-day injured list. |
| 2022-04-15 | 60-day | Casey Mize | Elbow | 2022-11-13 | The Detroit Tigers placed RHP Casey Mize on the 60-day injured list with a right elbow sprain. |
| 2022-04-14 | 60-day | John Means | Elbow | 2022-11-13 | The Baltimore Orioles placed LHP John Means on the 60-day injured list with a left elbow strain. |
| 2022-04-13 | 60-day | Austin Adams | Forearm | 2022-11-13 | The San Diego Padres have placed RHP Austin Adams on the 60-Day injured list. |
| 2022-04-12 | 60-day | Jorge Alcala | Elbow | 2022-11-13 | The Minnesota Twins placed RHP Jorge Alcala on the 60-day injured list with right elbow inflammation. |
| 2022-04-07 | 10-day | Ryan Sherriff | Shoulder | 2022-04-22 | The Philadelphia Phillies placed LHP Ryan Sherriff on the 10-day injured list with a left shoulder strain. |
| 2022-04-07 | 10-day | Garrett Crochet | Elbow | 2023-04-01 | The Chicago White Sox placed LHP Garrett Crochet on the 10-day injured list with a left elbow injury. |
| 2022-04-07 | 10-day | Casey Sadler | Shoulder | 2023-04-01 | The Seattle Mariners placed RHP Casey Sadler on the 10-day injured list with a right shoulder labrum injury. |
| 2022-04-07 | 10-day | Josh Taylor | Back | 2022-04-22 | The Boston Red Sox placed LHP Josh Taylor on the 10-day injured list with a low back strain. |
| 2022-04-07 | 60-day | Victor González | Elbow | 2022-11-13 | The Los Angeles Dodgers placed LHP Victor González on the 60-day injured list. |
| 2022-04-06 | 10-day | Kyle Funkhouser | Shoulder | 2022-05-01 | The Detroit Tigers placed RHP Kyle Funkhouser on the 10-day injured list with a right shoulder strain. |
| 2022-04-06 | 60-day | John Curtiss | Elbow | 2022-11-13 | The New York Mets placed RHP John Curtiss on the 60-day injured list. |
| 2022-04-05 | 60-day | Stephen Ridings | Shoulder | 2022-11-13 | The New York Yankees placed RHP Stephen Ridings on the 60-day injured list with a right shoulder impingement. |
| 2022-04-04 | 60-day | Ryan Rolison | Shoulder | 2022-11-13 | The Colorado Rockies placed LHP Ryan Rolison on the 60-day injured list with a left shoulder strain. |
| 2022-04-04 | 60-day | Sean Guenther | Arm | 2022-11-13 | The Miami Marlins placed LHP Sean Guenther on the 60-day injured list. |
| 2022-04-03 | 60-day | Luke Jackson | Elbow | 2022-11-13 | The Atlanta Braves placed RHP Luke Jackson on the 60-day injured list. |
| 2022-03-31 | Out | Will Harris | Shoulder | 2022-04-22 | Harris will likely start the year on the IL with lingering issues from shoulder surgery last year. |
| 2022-03-31 | Out | Trey Wingenter | Elbow | 2022-05-15 | Wingenter has been shut down due to elbow issuesR and won't be ready for the start of the season. |
| 2022-03-27 | Out | Deolis Guerra | Forearm | 2022-05-31 | Guerra is having surgery to address forearm tightness. |
| 2022-03-24 | 60-day | Jonathan Stiever | Lat | 2022-06-15 | Stiever has a right lat injury, and there is no timetable for his return. |
| 2022-03-24 | 60-day | Joe Ross | Elbow | 2022-05-15 | Ross is out 6-8 weeks after surgery to remove bone spurs from his right elbow. |
| 2022-03-24 | 60-day | Carter Kieboom | Forearm | 2022-05-15 | Kieboom is out with a flexor mass strain on his right forearm. He may return in May. |
| 2022-03-24 | 60-day | Fernando Tatis Jr. | Wrist | 2022-06-15 | Tatis had surgery to repair his fractured left wrist. |
| 2022-03-24 | 60-day | Blake Cederlind | Elbow | 2022-05-30 | Cederlind s recovering from Tommy John surgery last March. |
| 2022-03-24 | 60-day | Joey Lucchesi | Elbow | 2022-08-15 | Lucchesi is recovering from Tommy John surgery last June. |
| 2022-03-24 | 60-day | Kenta Maeda | Elbow | 2022-08-15 | Maeda hopes to pitch this year after Tommy John surgery last September. |
| 2022-03-24 | 60-day | Chris Rodriguez | Shoulder | 2022-08-15 | Rodriguez will miss most of the season after shoulder surgery last October. |
| 2022-03-24 | 60-day | Griffin Canning | Back | 2022-06-01 | Canning has a stress fracture in his back. |
| 2022-03-24 | 60-day | Jimmy Nelson | Elbow | 2022-09-15 | Nelson is recovering from Tommy John surgery last August. |
| 2022-03-24 | 60-day | Danny Duffy | Elbow | 2022-06-15 | Duffy may be out until June recovering from elbow surgery last October. |
| 2022-03-24 | 60-day | Scott Oberg | Elbow | 2022-09-15 | Oberg is out indefinitely after surgery to remove blood clots in his elbow. |
| 2022-03-24 | 60-day | Codi Heuer | Elbow | 2023-04-01 | Heuer will miss the 2022 season recovering from Tommy John surgery. |
| 2022-03-24 | 60-day | Brad Wieck | Elbow | 2022-06-30 | Wieck has an elbow strain. |
| 2022-03-24 | 60-day | James Paxton | Elbow | 2022-07-30 | He is recoving from Tommy John surgery in early 2021 |
| 2022-03-24 | Out | Alex Reyes | Shoulder | 2022-06-01 | Reyes will be out until late May or June with a frayed labrum. |
| 2022-03-24 | Out | Drew Pomeranz | Forearm | 2022-05-01 | Pomeranz is playing catch, but unlikely to pitch in April. |
| 2022-03-24 | Out | Pedro Báez | Hamate | 2022-05-15 | Kelly is not expected to be ready for opening day. |
| 2022-03-24 | Out | Spencer Turnbull | Elbow | 2022-09-15 | Turnbull will miss most of 2022 after July Tommy John surgery. |
| 2022-03-24 | Out | Jake Rogers | Elbow | 2022-09-15 | Rogers will miss most of the season after September Tommy John surgery. |
| 2022-03-24 | Out | Tejay Antone | Elbow | 2022-10-01 | Antone is recovering from Tommy John surgery last August. |
| 2022-03-24 | Out | Miguel Amaya | Elbow | 2023-04-01 | Amaya will miss the 2022 season recovering from Tommy John surgery. |
| 2022-03-24 | Out | Isaac Mattson | Shoulder | 2022-04-22 | He should be recoverd from tendonitis by mid-April |