| Date | Status | Player | Injury | Target Return? | Prognosis |
|---|
| 2022-10-01 | 60-day | Emmanuel Rivera | Wrist | 2022-11-30 | The Arizona Diamondbacks placed INF Emmanuel Rivera on the 60-day injured list. |
| 2022-09-30 | 60-day | Zack Britton | Shoulder | 2022-11-29 | The New York Yankees placed LHP Zack Britton on the 60-day injured list with left shoulder fatigue. |
| 2022-09-28 | 60-day | Matt Manning | Forearm | 2022-11-27 | The Detroit Tigers placed RHP Matt Manning on the 60-day injured list. |
| 2022-09-27 | 60-day | Sandy León | Knee | 2022-11-26 | The Minnesota Twins placed C Sandy León on the 60-day injured list. |
| 2022-09-21 | 60-day | Nick Anderson | Foot | 2022-11-20 | The Tampa Bay Rays placed RHP Nick Anderson on the 60-day injured list due to plantar fasciitis. |
| 2022-09-14 | 60-day | Nick Solak | Foot | 2022-11-13 | The Texas Rangers placed OF Nick Solak on the 60-day injured list with a right foot fracture. |
| 2022-09-13 | 60-day | Andrew Velazquez | Foot | 2022-11-12 | The Los Angeles Angels transferred INF Andrew Velazquez to the 60-day injured list. |
| 2022-09-12 | 60-day | Brandon Lowe | Back | 2022-11-11 | The Tampa Bay Rays placed INF Brandon Lowe on the 60-day injured list. |
| 2022-09-10 | 60-day | Brendan McKay | Elbow | 2022-11-09 | The Tampa Bay Rays placed LHP Brendan McKay on the 60-day injured list. |
| 2022-09-09 | 60-day | Brad Miller | Hip | 2022-11-08 | The Texas Rangers placed INF Brad Miller on the 60-day injured list. |
| 2022-09-05 | 60-day | Franchy Cordero | Ankle | 2022-11-13 | The Boston Red Sox placed INF Franchy Cordero on the 60-day injured list. |
| 2022-09-04 | 60-day | Jhonathan Díaz | Undisclosed | 2022-11-13 | The Los Angeles Angels placed LHP Jhonathan Diaz on the 60-day injured list. |
| 2022-08-30 | 60-day | Josh Sborz | Elbow | 2022-11-13 | The Texas Rangers placed RHP Josh Sborz on the 60-day injured list with a right elbow sprain. |
| 2022-08-28 | 60-day | Luis Gil | Elbow | 2022-11-13 | The New York Yankees placed RHP Luis Gil from on the 60-day injured list. |
| 2022-08-27 | 60-day | Dany Jiménez | Shoulder | 2022-11-13 | The Oakland Athletics placed RHP Dany Jiménez on the 60-day injured list with a right shoulder strain. |
| 2022-08-27 | 60-day | Ryan Thompson | Triceps | 2022-11-13 | The Tampa Bay Rays placed RHP Ryan Thompson on the 60-day injured list. |
| 2022-08-25 | 60-day | Jared Walsh | Rib | 2022-11-13 | The Los Angeles Angels placed INF Jared Walsh on the 60-day injured list. |
| 2022-08-10 | 60-day | Paul Blackburn | Finger | 2022-11-13 | The Oakland Athletics placed RHP Paul Blackburn on the 60-day injured list and will be shutdown for the remainder of the season. |
| 2022-08-09 | 60-day | Tanner Houck | Back | 2022-11-13 | The Boston Red Sox placed RHP Tanner Houck on the 60-day injured list. |
| 2022-08-02 | 60-day | Alex Kirilloff | Wrist | 2022-11-13 | The Minnesota Twins transferred OF/IF Alex Kirilloff to the 60-day injured list. |
| 2022-08-01 | 60-day | Tarik Skubal | Arm | 2022-11-13 | The Detroit Tigers transferred LHP Tarik Skubal to the 60-day injured list. |
| 2022-07-30 | 60-day | Miguel Sanó | Knee | 2022-11-13 | The Minnesota Twins placed INF Miguel Sanó on the 60-day injured list. |
| 2022-07-26 | 60-day | Angel Zerpa | Knee | 2022-11-13 | The Kansas City Royals placed LHP Angel Zerpa on the 60-day injured list. |
| 2022-07-24 | 60-day | Rony García | Bicep | 2022-11-13 | The Detroit Tigers placed RHP Rony GarcÃa on the 60-day injured list. |
| 2022-07-23 | 60-day | Michael King | Elbow | 2022-11-13 | The New York Yankees placed RHP Michael King on the 60-day injured list with a right elbow fracture. |
| 2022-07-18 | 60-day | Beau Brieske | Forearm | 2022-11-13 | The Detroit Tigers transferred RHP Beau Brieske to the 60-day injured list. |
| 2022-07-17 | 60-day | Chris Sale | Finger | 2022-11-13 | The Boston Red Sox placed LHP Chris Sale on the 60-day injured list. |
| 2022-07-11 | 60-day | Mitch Garver | Forearm | 2022-11-13 | The Texas Rangers placed C Mitch Garver on the 60-day injured list. |
| 2022-07-11 | 60-day | Shane Baz | Elbow | 2022-11-13 | The Tampa Bay Rays placed RHP Shane Baz on the 60-day injured list. |
| 2022-07-09 | 60-day | Kevin Kiermaier | Hip | 2022-11-13 | The Tampa Bay Rays placed OF Kevin Kiermaier on the 60-day injured list. |
| 2022-07-03 | 60-day | Anthony Gose | Triceps | 2022-11-13 | The Cleveland Guardians placed LHP Anthony Gose on the 60-day injured list with a left tricep strain. |
| 2022-07-01 | 60-day | Jason Castro | Knee | 2022-11-13 | The Houston Astros transferred C Jason Castro to the 60-day injured list. |
| 2022-06-28 | 60-day | Austin Meadows | Mental Health | 2022-11-13 | The Detroit Tigers placed OF Austin Meadows on the 60-day injured list. |
| 2022-06-26 | 60-day | Michael Brantley | Shoulder | 2022-11-13 | The Houston Astros transferred OF Michael Brantley to the 60-day injured list. |
| 2022-06-25 | 60-day | Trevor Larnach | Core | 2022-11-13 | The Minnesota Twins placed OF Trevor Larnach on the 60-day injured list. |
| 2022-06-23 | 60-day | Josh James | Lat | 2022-11-13 | The Houston Astros placed RHP Josh James on the 60-day injured list with a right lat strain. |
| 2022-06-22 | 60-day | Danny Mendick | Knee | 2022-11-13 | The Chicago White Sox placed INF Danny Mendick on the 60-day injured list. |
| 2022-06-13 | 60-day | Eli White | Wrist | 2022-11-13 | The Texas Rangers placed OF Eli White on the 60-day injured list. |
| 2022-06-10 | 60-day | Mike Zunino | Shoulder | 2022-11-13 | The Tampa Bay Rays placed C Mike Zunino on the 60-day injured list with left shoulder inflammation. |
| 2022-06-08 | 60-day | Andrew Kittredge | Elbow | 2022-11-13 | The Tampa Bay Rays placed RHP Andrew Kittredge on the 60-day injured list. |
| 2022-06-03 | 60-day | J.P. Feyereisen | Shoulder | 2022-11-13 | The Tampa Bay Rays transferred RHP J.P. Feyereisen from the 15-day injured list to the 60-day injured list with a right shoulder impingement. |
| 2022-06-01 | 60-day | Hyun Jin Ryu | Forearm | 2022-11-13 | The Toronto Blue Jays placed LHP Hyun Jin Ryu on the 60-day injured list with left forearm inflammation. |
| 2022-05-29 | 60-day | Royce Lewis | Knee | 2022-11-13 | The Minnesota Twins placed INF Royce Lewis on the 60-day injured list. |
| 2022-05-22 | 60-day | Cody Stashak | Shoulder | 2022-11-13 | The Minnesota Twins placed RHP Cody Stashak on the 60-day injured list. |
| 2022-05-20 | 60-day | Daulton Jefferies | Arm | 2022-11-13 | The Oakland Athletics placed RHP Daulton Jeffries on the 60-day injured list. |
| 2022-05-19 | 60-day | Chad Green | Elbow | 2022-11-13 | The New York Yankees placed RHP Chad Green on the 60-day injured list. |
| 2022-05-09 | 60-day | Chris Paddack | Elbow | 2022-11-13 | The Twins placed RHP Chris Paddack on the 60-day injured list. |
| 2022-05-06 | 60-day | Tom Murphy | Shoulder | 2022-11-13 | The Seattle Mariners placed C Tom Murphy on the 60-day injured list. |
| 2022-04-30 | 60-day | Jake Brentz | Flexor | 2022-11-13 | The Kansas City Royals transferred LHP Jake Brentz from the 10-day injured list to the 60-day injured list with a left flexor strain. |
| 2022-04-29 | 60-day | Tayler Saucedo | Hip | 2022-11-13 | The Toronto Blue Jays placed LHP Tayler Saucedo on the 60-day injured list. |
| 2022-04-26 | 60-day | Adalberto Mondesi | Knee | 2022-11-13 | The Kansas City Royals placed INF Adalberto Mondesi on the 60-day injured list. |
| 2022-04-15 | 60-day | Casey Mize | Elbow | 2022-11-13 | The Detroit Tigers placed RHP Casey Mize on the 60-day injured list with a right elbow sprain. |
| 2022-04-14 | 60-day | John Means | Elbow | 2022-11-13 | The Baltimore Orioles placed LHP John Means on the 60-day injured list with a left elbow strain. |
| 2022-04-12 | 60-day | Jorge Alcala | Elbow | 2022-11-13 | The Minnesota Twins placed RHP Jorge Alcala on the 60-day injured list with right elbow inflammation. |
| 2022-04-07 | 10-day | Garrett Crochet | Elbow | 2023-04-01 | The Chicago White Sox placed LHP Garrett Crochet on the 10-day injured list with a left elbow injury. |
| 2022-04-07 | 10-day | Casey Sadler | Shoulder | 2023-04-01 | The Seattle Mariners placed RHP Casey Sadler on the 10-day injured list with a right shoulder labrum injury. |
| 2022-04-07 | 10-day | Josh Taylor | Back | 2022-04-22 | The Boston Red Sox placed LHP Josh Taylor on the 10-day injured list with a low back strain. |
| 2022-04-06 | 10-day | Kyle Funkhouser | Shoulder | 2022-05-01 | The Detroit Tigers placed RHP Kyle Funkhouser on the 10-day injured list with a right shoulder strain. |
| 2022-04-05 | 60-day | Stephen Ridings | Shoulder | 2022-11-13 | The New York Yankees placed RHP Stephen Ridings on the 60-day injured list with a right shoulder impingement. |
| 2022-03-27 | Out | Deolis Guerra | Forearm | 2022-05-31 | Guerra is having surgery to address forearm tightness. |
| 2022-03-24 | 60-day | Jonathan Stiever | Lat | 2022-06-15 | Stiever has a right lat injury, and there is no timetable for his return. |
| 2022-03-24 | 60-day | Kenta Maeda | Elbow | 2022-08-15 | Maeda hopes to pitch this year after Tommy John surgery last September. |
| 2022-03-24 | 60-day | Chris Rodriguez | Shoulder | 2022-08-15 | Rodriguez will miss most of the season after shoulder surgery last October. |
| 2022-03-24 | 60-day | Griffin Canning | Back | 2022-06-01 | Canning has a stress fracture in his back. |
| 2022-03-24 | 60-day | James Paxton | Elbow | 2022-07-30 | He is recoving from Tommy John surgery in early 2021 |
| 2022-03-24 | Out | Pedro Báez | Hamate | 2022-05-15 | Kelly is not expected to be ready for opening day. |
| 2022-03-24 | Out | Spencer Turnbull | Elbow | 2022-09-15 | Turnbull will miss most of 2022 after July Tommy John surgery. |
| 2022-03-24 | Out | Jake Rogers | Elbow | 2022-09-15 | Rogers will miss most of the season after September Tommy John surgery. |
| 2022-03-24 | Out | Isaac Mattson | Shoulder | 2022-04-22 | He should be recoverd from tendonitis by mid-April |