| 15:07 | Dodgers | Tyler Glasnow | 4-1 2.92 | @ | Blue Jays | Yusei Kikuchi | 2-1 2.28 | ||
| 16:05 | Cardinals | Sonny Gray | 2-1 1.04 | @ | Mets | Adrian Houser | 0-2 7.45 | ||
| 16:05 | Athletics | JP Sears | 1-1 3.38 | @ | Orioles | Cole Irvin | 1-1 4.64 | ||
| 16:05 | Reds | Hunter Greene | 0-2 4.55 | @ | Rangers | Michael Lorenzen | 2-0 2.45 | ||
| 16:10 | Cubs | Ben Brown | 0-0 3.72 | @ | Red Sox | Josh Winckowski | 1-1 4.20 | ||
| 16:10 | Nationals | Mitchell Parker | 2-0 1.50 | @ | Marlins | Edward Cabrera | 1-0 3.27 | ||
| 18:05 | Astros | Ronel Blanco | 2-0 1.33 | @ | Rockies | Cal Quantrill | 0-2 4.33 | ||
| 18:10 | Royals | Brady Singer | 2-1 2.76 | @ | Tigers | Casey Mize | 1-0 2.95 | ||
| 19:10 | Yankees | Carlos Rodón | 1-1 2.70 | @ | Brewers | Joe Ross | 1-2 4.05 | ||
| 19:10 | Rays | Aaron Civale | 2-2 3.90 | @ | White Sox | Jonathan Cannon | 0-1 7.27 | ||
| 19:20 | Guardians | Tanner Bibee | 2-0 4.44 | @ | Braves | Charlie Morton | 2-0 4.70 | ||
| 20:40 | Phillies | Ranger Suárez | 4-0 1.36 | @ | Padres | Dylan Cease | 3-1 1.82 | ||
| 21:05 | Pirates | Martín Pérez | 1-1 3.45 | @ | Giants | Jordan Hicks | 2-0 1.61 | ||
| 21:38 | Twins | Chris Paddack | 1-1 5.57 | @ | Angels | José Soriano | 0-3 3.43 | ||
| 21:40 | Diamondbacks | Slade Cecconi | 1-0 3.00 | @ | Mariners | George Kirby | 2-2 5.33 |