| 12:35 | Brewers | Freddy Peralta | 2-0 1.90 | @ | Pirates | Mitch Keller | 2-2 4.80 | ||
| 13:10 | Red Sox | Chase Anderson | 0-0 2.77 | @ | Guardians | Triston McKenzie | 2-2 5.00 | ||
| 13:10 | Phillies | Zack Wheeler | 1-3 2.30 | @ | Reds | Nick Martinez | 0-0 4.76 | ||
| 13:10 | White Sox | Michael Soroka | 0-3 7.50 | @ | Twins | Simeon Woods Richardson | 1-0 1.50 | ||
| 14:10 | Blue Jays | José Berríos | 4-0 0.85 | @ | Royals | Cole Ragans | 0-2 4.32 | ||
| 14:20 | Astros | Justin Verlander | 1-0 3.00 | @ | Cubs | Javier Assad | 2-0 2.11 | ||
| 14:35 | Mariners | Luis Castillo | 1-4 4.40 | @ | Rangers | Andrew Heaney | 0-2 6.35 | ||
| 15:10 | Padres | Randy Vásquez | 0-1 1.80 | @ | Rockies | Dakota Hudson | 0-4 5.06 | ||
| 16:05 | Dodgers | Yoshinobu Yamamoto | 1-1 4.50 | @ | Nationals | MacKenzie Gore | 2-1 3.60 | ||
| 19:05 | Athletics | Alex Wood | 0-2 7.89 | @ | Yankees | Nestor Cortes | 1-1 3.41 |