| 13:05 | Braves | Reynaldo López | 3-2 1.74 | @ | Orioles | Cole Irvin | 6-2 2.87 | ||
| 13:10 | Nationals | Patrick Corbin | 1-7 6.15 | @ | Tigers | Casey Mize | 1-4 4.73 | ||
| 14:10 | Yankees | Nestor Cortes | 3-5 3.68 | @ | Royals | Alec Marsh | 5-3 4.05 | ||
| 14:15 | Pirates | Mitch Keller | 8-3 3.16 | @ | Cardinals | Lance Lynn | 2-3 3.58 | ||
| 18:50 | Cubs | Justin Steele | 0-3 4.26 | @ | Rays | Taj Bradley | 1-4 5.17 | ||
| 19:10 | Phillies | Aaron Nola | 8-2 2.77 | @ | Red Sox | Tanner Houck | 6-5 2.01 | ||
| 19:10 | Marlins | Roddery Muñoz | 1-2 5.95 | @ | Mets | Luis Severino | 4-2 3.25 | ||
| 19:40 | Athletics | Luis Medina | 0-1 5.23 | @ | Twins | Joe Ryan | 4-5 3.30 | ||
| 21:40 | Angels | Griffin Canning | 2-6 4.65 | @ | Diamondbacks | Brandon Pfaadt | 2-5 4.60 | ||
| 21:40 | White Sox | Garrett Crochet | 6-5 3.33 | @ | Mariners | Luis Castillo | 5-7 3.46 | ||
| 22:10 | Rangers | Michael Lorenzen | 3-3 3.05 | @ | Dodgers | Michael Grove | 4-2 4.72 |