McCoy (hamstring) could be out until November, CBS Sports reports.

McCoy is sidelined with a hamstring injury that he suffered back in preseason, and while he tried to play through it, the team is now going to hold him out until he is 100 percent healthy. With Karlos Williams (concussion) also sidelined, the Bills are expected to start Anthony Dixon in Week 5 against the Titans, with newly-signed Dan Herron the backup.

McCoy, who was ruled out for Sunday's game against the Titans, relayed Friday that he has been dealing with a Grade 2 hamstring pull, ESPN.com reports.

McCoy, who aggravated his hamstring injury during practice in Week 3, indicated that his injury is typically a three-to-four week issue, which clouds his status for the Bills' next two games in advance of their Week 8 bye, namely an Oct. 18 contest against the Bengals and an Oct. 25 tilt against the Jaguars in London.

McCoy (calf) will miss his second straight game this week, as he's been officially ruled out for Sunday's game in Tennessee.Vic Carucci of The Buffalo News reports.

So is hot rookie Karlos Williams due to a concussion. What once looked like a deep strongpoint for the Buffalo offense heading into this season is now in a state of flux, as McCoy can't get healthy, Williams won't be allowed to play again until he's cleared from the always scary concussion injury, and Fred Jackson is off in Seattle. Anthony Dixon will lead the charge this week with a mix of newcomer Dan Herron and the little known Cierre Wood.

McCoy (hamstring) did not take part in Friday's practice, Chris Brown of the Bills' website reports.

McCoy did not practice at all this week, so his chances of suiting up in Week 5 are not promising. Fellow running back Karlos Williams also sat out Friday for the third day in a row, so the Bills could be forced to start their third running back -- Anthony Dixon -- in this week's matchup with the Titans.

McCoy (hamstring) did not practice Thursday, ESPN's Mike Rodak reports.

Karlos Williams (concussion) was also absent from Thursday's practice, with both players remaining pretty iffy for Week 5. If neither McCoy or Williams can play, Anthony Dixon would be in line to start at running back for the Bills in Sunday's game against the Titans.

Neither McCoy (hamstring) or Karlos Williams (concussion) will practice Wednesday, wgr550.com reports.

At this stage, neither of the two backs have been ruled out for Sunday's game against the Titans, but in the event that they both end up sitting, Anthony Dixon would be in line to head the Bills' Week 5 backfield.

Following Sunday's loss to the Giants, coach Rex Ryan declined to offer a long-term prognosis for McCoy (hamstring), suggesting that the running back's status is a "day-to-day, week-to-week" situation.

Previous reports have suggested that McCoy isn't inclined to play until he is 100 percent and could miss 3-4 weeks, though at this stage he has yet to be officially ruled out by the Bills for Week 5's game against the Titans. Unless things look up for McCoy in short order though, we'd expect Karlos Williams to draw another start at running back for the Bills in this coming Sunday's road game.

The Buffalo News relays that McCoy could miss 3-4 weeks after a MRI revealed a new tear in the running back's balky hamstring.

We'll continue to monitor McCoy's status in the coming days, but barring some new and improved injury info on this front, it appears as though rookie Karlos Williams is destined to continue to see added work in the coming weeks, while McCoy recovers from his hamstring issue, which originally surfaced on Aug. 18.

McCoy, already ruled out for Sunday's game against the Giants, says he won't play again until his injured hamstring is at full health, the Associated Press reports. "One thing I just promised myself is I can't go out there if I'm not 100 percent," McCoy said. "Whatever it is, I'm rushing to get back, but I'm not playing until I'm 100 percent."

We'll see if one week off does the trick, but McCoy suffered a setback leading into the Week 3 game in Miami, and so far there's been no indication he's made marked improvement.

McCoy has now been officially ruled out for Sunday's game against the Giants, ESPN's Mike Rodak reports.

We knew this was coming, and the big question for McCoy owners - who probably paid a hefty price for very minimal production so far - will be whether one week off is enough to get him back in playable condition again. Hopefully you were first in line for the Karlos Williams Sale.

McCoy (hamstring) will not practice Friday, ESPN's Mike Rodak reports.

It certainly seems as if McCoy will be held out of Sunday's game against the Giants as he continues to deal with a lingering hamstring issue, however nothing official has been announced as of yet. If McCoy is unable to go, the explosive rookie Karlos Williams will likely get the majority of the snaps at running back.

After missing practice Wednesday with continued hamstring problems, McCoy was unable to practice Thursday as well, Tyler Dunne of The Buffalo News reports.

At this point it's looking doubtful McCoy will be able to suit up Sunday against the Giants, with the Bills seemingly ready to rest him for a week and let rookie Karlos Williams carry the mail.

Coach Rex Ryan says it's a real possibility that McCoy (hamstring) won't play this week against the Giants.

We'll assume Shady isn't going to practice Wednesday, and with his status in doubt - maybe significant doubt - for this week, owners should be rushing to the wire to pick up Karlos Williams.

NFL Network's Rand Getlin says McCoy may be unlikely to play this week in an effort to get his injured hamstring healed.

The Bills have an inter-conference game against the Giants this week - a game where they'll be favored - and seem to be OK if rookie Karlos Williams continues to show his stuff while McCoy has a longer chance to heal. We're not ruling out McCoy just yet, but you should probably start making plans early in the week if you own him.

McCoy (hamstring) acknowledged that he might need to miss a game, Tyler Dunne of the Buffalo News reports.

Bills head coach Rex Ryan hopes McCoy can keep playing, even though the running back is limited by his hamstring. McCoy managed just 26 yards and a touchdown on 12 touches in Sunday's 41-14 win over the Dolphins, eventually giving way to Karlos Williams and Anthony Dixon in the second half. Williams gained 110 yards on 12 carries, highlighted by a 41-yard touchdown. It sounds like McCoy could use a week or two of rest, but he may be healthy enough to split the workload with Williams in Week 4 against the Giants.

Bills head coach Rex Ryan said after Sunday's game that McCoy (hamstring) is still playing on "one-and-a-half legs", Joe Buscaglia of WKBW reports.

McCoy was held to just 16 yards on 11 carries in Sunday's 41-14 win over the Dolphins, but he did score a 10-yard touchdown on his only reception. Karlos Williams got more work than McCoy in the second half, ultimately finishing with 12 carries for 110 yards and a touchdown. McCoy may split snaps with Williams, but Bills head coach Rex Ryan said he plans to keep playing the veteran running back, even if he's only at 80 percent health, Tyler Dunne of the Buffalo News reports. The Bills have a home date with the Giants in Week 4.

McCoy (hamstring) is listed as active for Sunday's game against the Dolphins.

McCoy, who rushed 15 times for 89 yards and added three catches for 27 yards in Week 2's game against the Patriots, on thus in line to continue to head the Buffalo rushing attack on Sunday against Miami, backed up by Karlos Williams.

Though McCoy (hamstring) practiced on a limited basis Friday, he is listed as probable for Sunday's game against the Dolphins, the Buffalo News reports.

McCoy rushed 15 times for 89 yards and added three catches for 27 yards last Sunday against the Patriots, and given that no injury setbacks have been reported since then, he's on track to continue to head the Bills' rushing attack (backed up by Karlos Williams) on Sunday against Miami.

McCoy (hamstring) practiced fully Thursday, ESPN's Mike Rodak reports.

More importantly, coach Rex Ryan said Thursday that he isn't concerned about McCoy's availability for Sunday's game against the Dolphins. Unless the running back's hamstring flares up at all, McCoy is trending toward an official probable designation on the Bills' final Week 3 injury report.

McCoy (hamstring) returned to practice Thursday, ESPN's Mike Rodak reports.

We'll note McCoy's level of participation after the Bills do so, but his return to the field Thursday solidifies the idea that the running back will continue to play through his hamstring issue this Sunday against the Dolphins.