Holmes (ankle) took a majority of the first-team snaps during Wednesday's practice, the Indianapolis Star reports.

Colts head coach Chuck Pagano isn't committing Holmes to start Sunday against Jacksonville, but his work with the first team Wednesday is a good sign. Holmes will be evaluated Thursday to see how he responds to Wednesday's practice.

Holmes (ankle) is listed as inactive for Sunday night's regular season opener against the Broncos.

Holmes is still short of health after spraining his ankle during the preseason. While Holmes remains sidelined, A.Q. Shipley is expected to start at center for the Colts.

Holmes (ankle) did not practice Friday and is listed as questionable for Sunday's game at Denver, the Colts' official site reports.

It doesn't look like Holmes will return this week from a sprained ankle suffered in the preseason.

Holmes (ankle) was a limited participant at Wednesday's practice, the Colts' official site reports.

This is a step toward Holmes being able to play Sunday night in Denver. We'll need to see how the ankle responds Thursday and look for Holmes to increase his practice regime.

The Colts expect Holmes (sprained ankle) to be ready for the Sept. 7 season opener against the Broncos, ESPN reports.

Holmes sprained his ankle in Thursday's preseason game and is expected to be sidelined several weeks. While Holmes may not miss any regular season games, it's not ideal that he'll miss preseason games and practice time since he played just four games last season and is expected to be the starting center this year.

The Colts believe Holmes suffered a sprained ankle, which will likely cause him to miss a few weeks, Mike Chappell of the Indianapolis Star reports.

Holmes will undergo an MRI to confirm these suspicions, but it's likely safe to rule him out for the remainder of the preseason. Quarterback Andrew Luck will have to make due with a backup center for the rest of the Colts' exhibition games, with the hopes of having his regular guy back for Week 1.

Holmes will get an MRI on his ankle Friday, the Indianapolis Star reports.

Coach Chuck Pagano wasn't able to give an update on Holmes' status, so his injury should become more clear after his MRI on Friday.

Holmes limped off the field during the first quarter of Thursday's preseason opener after sustaining an ankle injury, NFL.com reports.

Holmes is considered questionable to return. Injuries limited the rookie to just four games last season, so the Colts will hope Thursday's incident isn't serious.

Colts GM Ryan Grigson said the team has "plans" for second-year C Khaled Holmes, but insisted the 2013 fourth-round pick would not be handed the center position.

The retirement of C Phil Costa made Holmes the clear-cut favorite for the Colts' center position, but it would not be surprising if the team addresses the position in the draft. Indianapolis envisions itself as a power running team, and Holmes does not fit well into that mold. The Colts have some work to do to improve the interior of their offensive line.

The Colts plan to hold a camp battle at center between Phil Costa and 2013 fourth-round pick Khaled Holmes.

Holmes was an undersized project who managed 13 bench-press reps last year coming out of USC. He's considered a zone-blocking lineman, while the Colts prefer power under OC Pep Hamilton. Costa was an ascending pivot before Dallas gave him his walking papers. We'd view Costa as the favorite to start.