| Date | Status | Player | Injury | Target Return? | Prognosis |
|---|
| 2023-09-21 | Day-to-Day | Brandon Lowe | Knee | | Lowe left Thursday's (Sep. 21) game against the Angels. |
| 2023-09-21 | Day-to-Day | Luke Raley | Hand | | Raley is not in the lineup for Thursday's (Sep. 21) game against the Angels. |
| 2023-09-20 | 15-day | Gregory Santos | Elbow | 2023-10-05 | The Chicago White Sox placed RHP Gregory Santos on the 15-day injured list. |
| 2023-09-20 | Day-to-Day | Luis Urías | Calf | | Urias exited Wednesday's (Sep. 20) game with left calf tightness, per team. |
| 2023-09-19 | 15-day | Brady Singer | Lumbar Strain | 2023-10-04 | The Kansas City Royals placed RHP Brady Singer on the 15-day injured list. |
| 2023-09-19 | 15-day | Brad Keller | Thoracic Outlet Syndrome | 2023-10-04 | The Kansas City Royals placed RHP Brad Keller on the 15-day injured list. |
| 2023-09-19 | Day-to-Day | Royce Lewis | Hamstring | | Lewis is not in the lineup for Wednesday's (Sep. 20) game against Cincinnati. |
| 2023-09-19 | Day-to-Day | Everson Pereira | Hamstring | | Pereira is not in the lineup for Thursday's (Sep. 21) game against Toronto. |
| 2023-09-19 | Day-to-Day | Yusei Kikuchi | Trap Muscle Cramp | | Kikuchi exited his start on Tuesday (Sep. 19) with a left upper trap muscle cramp, per team. |
| 2023-09-19 | Day-to-Day | Javier Báez | Back | | Baez is not in the lineup for Thursday's (Sep. 21) game against Oakland. |
| 2023-09-18 | Day-to-Day | Carlos Correa | Foot | | Correa is not in the lineup for Wednesday's (Sep. 20) game against Cincinnati. |
| 2023-09-18 | Day-to-Day | Eduardo Rodriguez | Back | | Rodriguez left Monday's (Sep. 18) game against the Dodgers. |
| 2023-09-17 | 10-day | Ryan Mountcastle | Shoulder | 2023-09-27 | The Baltimore Orioles placed INF Ryan Mountcastle on the 10-day injured list. |
| 2023-09-17 | 60-day | Kyren Paris | Thumb | 2023-11-16 | The Los Angeles Angels placed INF Kyren Paris on the 60-day injured list with a left thumb ligament tear. |
| 2023-09-17 | 7-day | Salvador Perez | Concussion | 2023-09-24 | The Kansas City Royals placed C Salvador Perez on the 7-day injured list. |
| 2023-09-17 | Day-to-Day | Michael Brantley | General Soreness | | Brantley is not in the lineup for Wednesday's (Sep. 20) game against Baltimore. |
| 2023-09-16 | 10-day | Triston Casas | Shouder | 2023-09-26 | The Boston Red Sox placed INF Triston Casas on the 10-day injured list with right shoulder inflammation. |
| 2023-09-16 | 15-day | Tanner Bibee | Hip | 2023-10-01 | The Cleveland Guardians placed RHP Tanner Bibee on the 15-day injured list. |
| 2023-09-16 | 15-day | Shohei Ohtani | Oblique | 2023-10-01 | The Los Angeles Angels placed RHP Shohei Ohtani on the 15-day injured list. |
| 2023-09-16 | 15-day | Alex Faedo | Finger | 2023-10-01 | The Detroit Tigers placed RHP Alex Faedo on the 15-day injured list. |
| 2023-09-16 | 60-day | Sean Newcomb | Knee | 2023-11-15 | The Oakland Athletics placed LHP Sean Newcomb on the 60-day injured list. |
| 2023-09-16 | 60-day | Greg Jones | Hamstring | 2023-11-15 | The Tampa Bay Rays recalled INF Greg Jones from the minors and placed him on the 60-day injured list. |
| 2023-09-16 | 60-day | Ian Kennedy | Shoulder | 2023-11-15 | The Texas Rangers placed RHP Ian Kennedy on the 60-day injured list with a right rotator cuff strain. |
| 2023-09-15 | 7-day | Anthony Misiewicz | Head | 2023-09-22 | The New York Yankees placed LHP Anthony Misiewicz on the 7-day injured list. |
| 2023-09-14 | 60-day | Terrin Vavra | Shoulder | 2023-11-13 | The Baltimore Orioles placed OF Terrin Vavra on the 60-day injured list. |
| 2023-09-13 | 7-day | Kenley Jansen | Covid-19 | 2023-09-29 | The Boston Red Sox placed RHP Kenley Jansen on the Covid Injured List. |
| 2023-09-12 | 10-day | Mike Moustakas | Forearm | 2023-09-22 | The Los Angeles Angels placed INF Mike Moustakas on the 10-day injured list with a left forearm extensor strain. |
| 2023-09-12 | 15-day | Max Scherzer | Triceps | 2023-09-27 | The Texas Rangers placed RHP Max Scherzer on the 15-day injured list. |
| 2023-09-11 | 10-day | Brandon Belt | Back | 2023-09-29 | The Toronto Blue Jays placed DH Brandon Belt on the 10-day injured list. |
| 2023-09-11 | 10-day | Jose Siri | Hand | 2023-09-29 | The Tampa Bay Rays placed OF Jose Siri on the 10-day injured list. |
| 2023-09-10 | 10-day | Jasson Domínguez | Elbow | 2023-09-29 | The New York Yankees placed OF Jasson Domínguez on the 10-day injured list. |
| 2023-09-10 | 15-day | Jonathan Loáisiga | Elbow | 2023-09-25 | The New York Yankees placed RHP Jonathan Loáisiga on the 15-day injured list. |
| 2023-09-10 | 15-day | James Paxton | Knee | 2023-09-25 | The Boston Red Sox placed LHP James Paxton on the 15-day injured list. |
| 2023-09-09 | 15-day | Declan Cronin | Hand | 2023-09-24 | The Chicago White Sox placed RHP Declan Cronin on the 15-day injured list with blisters on his right hand. |
| 2023-09-09 | 60-day | Austin Cox | Knee | 2023-11-08 | The Kansas City Royals placed LHP Austin Cox on the 60-day injured list with a left knee sprain. |
| 2023-09-09 | 60-day | Freddy Fermin | Finger | 2023-11-08 | The Kansas City Royals placed C Freddy Fermin on the 60-day injured list. |
| 2023-09-08 | 10-day | Joey Gallo | Foot | 2023-09-29 | The Minnesota Twins placed INF Joey Gallo on the 10-day injured list. |
| 2023-09-08 | 15-day | Albert Abreu | Hamstring | 2023-09-23 | The New York Yankees placed RHP Albert Abreu on the 15-day injured list. |
| 2023-09-08 | 15-day | Luis Severino | Side | 2023-09-23 | The New York Yankees placed RHP Luis Severino on the 15-day injured list with a left upper body injury. |
| 2023-09-07 | 10-day | Mickey Moniak | Back | 2023-09-29 | The Los Angeles Angels placed OF Mickey Moniak on the 10-day injured list with left back tightness. |
| 2023-09-07 | 15-day | Jaime Barría | Hamstring | 2023-09-22 | The Los Angeles Angels placed RHP Jaime Barría on the 15-day injured list. |
| 2023-09-07 | 15-day | Matt Manning | Foot | 2023-09-22 | The Detroit Tigers placed RHP Matt Manning on the 15-day injured list with a right foot fracture. |
| 2023-09-07 | 60-day | Luis Rengifo | Bicep | 2023-11-06 | The Los Angeles Angels transferred INF Luis Rengifo to the 60-day injured list. |
| 2023-09-05 | 15-day | Josh Sborz | Hamstring | 2023-09-29 | The Texas Rangers placed RHP Josh Sborz on the 15-day injured list. |
| 2023-09-04 | 15-day | Ryne Stanek | Ankle | 2023-09-29 | The Houston Astros placed RHP Ryne Stanek on the 15-day injured list. |
| 2023-09-03 | 15-day | Keynan Middleton | Shoulder | 2023-09-29 | The New York Yankees placed RHP Keynan Middleton on the 15-day injured list. |
| 2023-09-03 | 15-day | Jimmy Lambert | Ankle | 2023-09-29 | The Chicago White Sox placed RHP Jimmy Lambert on the 15-day injured list. |
| 2023-09-01 | 10-day | Danny Jansen | Finger | 2023-09-29 | The Toronto Blue Jays placed C Danny Jansen on the 10-day injured list with a right middle finger fracture. |
| 2023-09-01 | 60-day | Riley Greene | Elbow | 2023-10-31 | The Detroit Tigers transferred OF Riley Greene to the 60-day injured list. |
| 2023-08-29 | 15-day | Andrew Vasquez | Calf | 2023-09-29 | The Detroit Tigers placed LHP Andrew Vasquez on the 15-day injured list. |
| 2023-08-28 | 15-day | John McMillon | Forearm | 2023-09-29 | The Kansas City Royals placed RHP John McMillon on the 15-day injured list. |
| 2023-08-26 | 7-day | Chase Silseth | Head | 2023-09-29 | The Los Angeles Angels placed RHP Chase Silseth on the 7-day injured list. |
| 2023-08-25 | 15-day | Félix Bautista | Arm | 2023-09-29 | The Baltimore Orioles placed RHP Félix Bautista on the 15-day injured list. |
| 2023-08-23 | 10-day | Mike Trout | Hand | 2023-09-29 | The Los Angeles Angels placed OF Mike Trout on the 10-day injured list. |
| 2023-08-22 | 60-day | Oliver Ortega | Back | 2023-10-21 | The Minnesota Twins transferred RHP Oliver Ortega to the 60-day injured list with a left lumbar strain. |
| 2023-08-21 | 10-day | Billy McKinney | Back | 2023-09-29 | The New York Yankees placed OF Billy McKinney on the 10-day injured list. |
| 2023-08-21 | 60-day | Emerson Hancock | Shoulder | 2023-10-20 | The Seattle Mariners transferred RHP Emerson Hancock to the 60-day injured list. |
| 2023-08-20 | 60-day | Jarren Duran | Toe | 2023-10-19 | The Boston Red Sox transferred OF Jarren Duran to the 60-day injured list. |
| 2023-08-17 | 15-day | Austin Pruitt | Forearm | 2023-09-29 | The Oakland Athletics placed RHP Austin Pruitt on the 15-day injured list. |
| 2023-08-15 | 10-day | JJ Bleday | Knee | 2023-09-29 | The Oakland Athletics placed OF JJ Bleday on the 10-day injured list. |
| 2023-08-15 | 15-day | Angel Felipe | Elbow | 2023-09-29 | The Oakland Athletics placed RHP Angel Felipe on the 15-day injured list. |
| 2023-08-14 | 10-day | Tom Murphy | Thumb | 2023-09-29 | The Seattle Mariners placed C Tom Murphy on the 10-day injured list. |
| 2023-08-14 | 60-day | Freddy Tarnok | Calf | 2023-10-13 | The Oakland Athletics placed RHP Freddy Tarnok on the 60-day injured list. |
| 2023-08-11 | 60-day | Hagen Danner | Oblique | 2023-10-10 | The Toronto Blue Jays transferred RHP Hagen Danner to the 60-day injured list with a left oblique strain. |
| 2023-08-08 | 60-day | Nestor Cortes | Shoulder | 2023-10-07 | The New York Yankees placed LHP Nestor Cortes on the 60-day injured list. |
| 2023-08-03 | 60-day | Anthony Rizzo | Concussion | 2023-10-02 | The New York Yankees placed INF Anthony Rizzo on the 60-day injured list. |
| 2023-08-03 | 60-day | Shane McClanahan | Forearm | 2023-10-02 | The Tampa Bay Rays transferred LHP Shane McClanahan from the 15-day injured list to the 60-day injured list as he recovers from left forearm tightness. |
| 2023-08-02 | 10-day | Byron Buxton | Hamstring | 2023-09-29 | The Minnesota Twins placed DH Byron Buxton on the 10-day injured list. |
| 2023-08-02 | 60-day | Brad Miller | Hamstring | 2023-10-01 | The Texas Rangers transferred DH Brad Miller to the 60-day injured list. |
| 2023-08-01 | 60-day | Otto Lopez | Oblique | 2023-09-30 | The Toronto Blue Jays placed INF Otto Lopez on the 60-day injured list. |
| 2023-07-29 | 15-day | Joely Rodríguez | Hip | 2023-09-29 | The Boston Red Sox placed LHP Joely Rodríguez on the 15-day injured list. |
| 2023-07-29 | 60-day | Taylor Ward | Face | 2023-09-27 | The Los Angeles Angels placed OF Taylor Ward on the 60-day injured list. |
| 2023-07-23 | 15-day | Mason Englert | Hip | 2023-09-29 | The Detroit Tigers placed RHP Mason Englert on the 15-day injured list. |
| 2023-07-19 | 60-day | Daniel Lynch | Shoulder | 2023-09-29 | The Kansas City Royals placed LHP Daniel Lynch on the 60-day injured list. |
| 2023-07-18 | 60-day | Jose Trevino | Wrist | 2023-09-29 | The New York Yankees transferred C Jose Trevino to the 60-day injured list. |
| 2023-07-14 | 60-day | Jose Miranda | Shoulder | 2023-09-29 | The Minnesota Twins transferred INF Jose Miranda to the 60-day injured list. |
| 2023-07-14 | 60-day | Shane Bieber | Elbow | 2023-09-29 | The Cleveland Guardians transferred RHP Shane Bieber to the 60-day injured list. |
| 2023-07-14 | 60-day | Sam Bachman | Shoulder | 2023-09-29 | The Los Angeles Angels transferred RHP Sam Bachman to the 60-day injured list. |
| 2023-07-11 | 60-day | Richard Lovelady | Arm | 2023-09-29 | The Oakland Athletics placed LHP Richard Lovelady on the 60-day injured list. |
| 2023-07-07 | 60-day | Kaleb Ort | Elbow | 2023-09-29 | The Boston Red Sox placed RHP Kaleb Ort on the 60-day injured list. |
| 2023-07-04 | 60-day | Anthony Rendon | Shin | 2023-09-29 | The Los Angeles Angels transferred INF Anthony Rendon to the 60-day injured list with a left shin contusion. |
| 2023-07-03 | 60-day | Tyler Alexander | Shoulder | 2023-09-29 | The Detroit Tigers placed LHP Tyler Alexander on the 60-day injured list. |
| 2023-06-30 | 60-day | Yacksel Ríos | Finger | 2023-09-29 | The Oakland Athletics transferred RHP Yacksel Ríos to the 60-day injured list. |
| 2023-06-30 | 60-day | James Kaprielian | Shoulder | 2023-09-29 | The Oakland Athletics transferred RHP James Kaprielian to the 60-day injured list with a shoulder strain. |
| 2023-06-29 | 60-day | Keegan Akin | Back | 2023-09-29 | The Baltimore Orioles placed LHP Keegan Akin on the 60-day injured list. |
| 2023-06-27 | 60-day | Brock Stewart | Elbow | 2023-09-29 | The Minnesota Twins transferred RHP Brock Stewart to the 60-day injured list with elbow soreness. |
| 2023-06-26 | 60-day | Matthew Boyd | Elbow | 2023-09-29 | The Detroit Tigers placed LHP Matthew Boyd on the 60-day injured list with a left elbow sprain. |
| 2023-06-24 | 60-day | José De León | Elbow | 2023-09-29 | The Minnesota Twins transferred RHP José De León to the 60-day injured list. |
| 2023-06-24 | 60-day | Adam Cimber | Shoulder | 2023-09-29 | The Toronto Blue Jays transferred RHP Adam Cimber to the 60-day injured list. |
| 2023-06-21 | 60-day | Corey Kluber | Shoulder | 2023-09-29 | The Boston Red Sox transferred RHP Corey Kluber to the 60-day injured list. |
| 2023-06-18 | 60-day | Romy González | Shoulder | 2023-09-29 | The Chicago White Sox placed INF Romy González on the 60-day injured list. |
| 2023-06-15 | 60-day | Gio Urshela | Pelvis | 2023-09-29 | The Los Angeles Angels transferred INF Gio Urshela to the 60-day injured list. |
| 2023-06-14 | 60-day | Triston McKenzie | Elbow | 2023-09-29 | The Cleveland Guardians transferred RHP Triston McKenzie to the 60-day injured list. |
| 2023-06-12 | 60-day | Penn Murfee | Elbow | 2023-09-29 | The Seattle Mariners placed RHP Penn Murfee on the 60-day injured list. |
| 2023-06-10 | 60-day | Liam Hendriks | Elbow | 2023-09-29 | The Chicago White Sox transferred RHP Liam Hendriks to the 60-day injured list. |
| 2023-06-09 | 60-day | Vinnie Pasquantino | Shoulder | 2023-09-29 | The Kansas City Royals placed INF Vinnie Pasquantino on the 60-day injured list. |
| 2023-06-07 | 60-day | Josh Staumont | Neck | 2023-09-29 | The Kansas City Royals transferred RHP Josh Staumont to the 60-day injured list. |
| 2023-06-03 | 60-day | Ryan Weber | Forearm | 2023-09-29 | The New York Yankees transferred RHP Ryan Weber to the 60-day injured list. |
| 2023-06-02 | 60-day | Marco Gonzales | Forearm | 2023-09-29 | The Seattle Mariners transferred LHP Marco Gonzales to the 60-day injured list. |
| 2023-05-28 | 60-day | Josh Taylor | Shoulder | 2023-09-29 | The Kansas City Royals transferred LHP Josh Taylor to the 60-day injured list. |
| 2023-05-19 | 60-day | Zach Jackson | Elbow | 2023-09-29 | The Oakland Athletics placed RHP Zach Jackson on the 60-day injured list. |
| 2023-05-17 | 60-day | Nick Gordon | Shin | 2023-09-29 | The Minnesota Twins transferred INF Nick Gordon to the 60-day injured list. |
| 2023-05-17 | 60-day | Drew Rucinski | Illness | 2023-09-29 | The Oakland Athletics placed RHP Drew Rucinski on the 60-day injured list. |
| 2023-05-16 | 60-day | Jorge Alcala | Forearm | 2023-09-29 | The Minnesota Twins placed RHP Jorge Alcala on the 60-day injured list. |
| 2023-05-12 | 60-day | Drew Rasmussen | Flexor | 2023-09-29 | The Tampa Bay Rays placed RHP Drew Rasmussen on the 60-day injured list. |
| 2023-05-07 | 60-day | Garrett Cleavinger | Knee | 2023-09-29 | The Tampa Bay Rays placed LHP Garrett Cleavinger on the 60-day injured list. |
| 2023-05-03 | 60-day | Tyler Mahle | Arm | 2023-09-29 | The Minnesota Twins transferred RHP Tyler Mahle to the 60-day IL. |
| 2023-05-01 | 60-day | Luis Garcia | Elbow | 2023-09-29 | The Houston Astros transferred RHP Luis Garcia to the 60-day injured list. |
| 2023-04-30 | 60-day | Easton McGee | Forearm | 2023-09-29 | The Seattle Mariners transferred RHP Easton McGee to the 60-day injured list. |
| 2023-04-28 | 60-day | José Quijada | Elbow | 2023-09-29 | The Los Angeles Angels transferred LHP José Quijada to the 60-day injured list. |
| 2023-04-28 | 60-day | Jacob deGrom | Elbow | 2023-09-29 | The Texas Rangers transferred RHP Jacob deGrom to the 60-day injured list with right elbow inflammation. |
| 2023-04-24 | 60-day | Austin Warren | Elbow | 2023-09-29 | The Los Angeles Angels placed RHP Austin Warren on the 60-day injured list. |
| 2023-04-16 | 60-day | Kris Bubic | Flexor | 2023-09-29 | The Kansas City Royals placed LHP Kris Bubic on the 60-day injured list. |
| 2023-04-13 | 60-day | Jeffrey Springs | Elbow | 2023-09-29 | The Tampa Bay Rays transferred LHP Jeffrey Springs from the 15-day injured list to the 60-day injured list as he recovers from a left elbow flexor strain. |
| 2023-04-12 | 60-day | Zack Kelly | Elbow | 2023-09-29 | The Boston Red Sox placed RHP Zack Kelly on the 60-day injured list. |
| 2023-04-09 | 60-day | Evan White | Adductor | 2023-09-29 | The Seattle Mariners placed INF Evan White on the 60-day injured list. |
| 2023-04-08 | 60-day | Austin Meadows | Anxiety | 2023-09-29 | The Detroit Tigers transferred OF Austin Meadows to the 60-day injured list. |
| 2023-04-06 | 60-day | Matt Canterino | Undisclosed | 2023-09-29 | The Minnesota Twins placed RHP Matt Canterino on the 60-day injured list. |
| 2023-04-01 | 60-day | Robbie Ray | Flexor | 2023-09-29 | The Seattle Mariners transferred LHP Robbie Ray to the 60-day injured list. |
| 2023-03-30 | 15-day | Frankie Montas | Shoulder | 2023-08-15 | The New York Yankees placed RHP Frankie Montas on the 15-day injured list as he recovers from a right shoulder injury. |
| 2023-03-30 | 15-day | Lou Trivino | Elbow | 2023-05-15 | The New York Yankees placed RHP Lou Trivino on the 15-day injured list with a right elbow strain. |
| 2023-03-30 | 15-day | Lance McCullers Jr. | Elbow | 2023-05-30 | The Houston Astros placed RHP Lance McCullers Jr. on the 15-day injured list. |
| 2023-03-30 | 15-day | Wyatt Mills | Elbow | 2023-04-20 | The Boston Red Sox placed RHP Wyatt Mills on the 15-day injured list. |
| 2023-03-30 | 15-day | Dillon Tate | Undisclosed | 2023-05-16 | The Baltimore Orioles placed RHP Dillon Tate on the 15-day injured list. |
| 2023-03-29 | 15-day | Shane Baz | Elbow | 2023-10-02 | The Tampa Bay Rays placed RHP Shane Baz on the 15-day injured list due to an elbow injury. |
| 2023-03-29 | 60-day | Chris Rodriguez | Shoulder | 2023-09-29 | The Los Angeles Angels transferred RHP Chris Rodriguez from the 15-day injured list to the 60-day injured list as he recovers from a shoulder injury. |
| 2023-03-29 | 60-day | Freddy Pacheco | Elbow | 2023-09-29 | The Detroit Tigers placed RHP Freddy Pacheco on the 60-day injured list with a right elbow sprain. |
| 2023-03-27 | 60-day | Matt Foster | Forearm | 2023-09-29 | The Chicago White Sox transferred RHP Matt Foster from the 15-day injured list to the 60-day injured list as he recovers from a right flexor strain. |
| 2023-03-17 | Out | Jake Brentz | Shoulder | 2023-10-02 | Will miss the season after Tommy John surgery last July |
| 2023-03-01 | Out | Jake Odorizzi | Arm | 2023-04-30 | Expected to start the year on the injured list with arm fatigue. |
| 2023-01-17 | Out | Brett Martin | Shoulder | 2023-08-31 | Recovering from surgery in January |
| 2022-10-11 | Out | Scott Effross | Elbow | 2023-10-02 | Recovering from Tommy John surgery last October |
| 2022-05-21 | Out | Luis Gil | Elbow | 2023-08-30 | Recovering from Tommy John surgery last May |
| 2022-05-18 | 60-day | Chris Paddack | Elbow | 2023-07-30 | Recovering from Tommy John surgery last May |
| 2022-04-28 | Out | Adalberto Mondesi | Knee | 2023-04-30 | Recovering from surgery to repair a torn ACL |
| 2022-04-14 | 60-day | Casey Mize | Elbow | 2023-09-15 | Recovering from Tommy John surgery last June |
| Restricted | Domingo Germán | | | |
.