| Date | Status | Player | Injury | Target Return? | Prognosis |
|---|---|---|---|---|---|
| 2015-09-26 | 15-day | Billy Hamilton | |||
| 2015-09-26 | 60-day | Kristopher Negrón | |||
| 2015-09-21 | 60-day | Jung Ho Kang | |||
| 2015-09-12 | 60-day | Nick Hundley | |||
| 2015-09-02 | 60-day | Josh Ravin | |||
| 2015-09-01 | 60-day | Casey Sadler | |||
| 2015-08-30 | 60-day | Wilfredo Tovar | |||
| 2015-08-28 | 60-day | Denard Span | |||
| 2015-08-25 | 15-day | Kendry Flores | |||
| 2015-08-24 | 15-day | Jason Motte | |||
| 2015-08-20 | 15-day | Hunter Pence | |||
| 2015-08-20 | 60-day | Michael McKenry | |||
| 2015-08-17 | 15-day | David Phelps | |||
| 2015-08-12 | 15-day | Brandon Maurer | |||
| 2015-08-07 | 60-day | Deolis Guerra | |||
| 2015-08-05 | 15-day | Rafael Soriano | |||
| 2015-08-04 | 15-day | Jason Frasor | |||
| 2015-08-03 | 15-day | Carter Capps | |||
| 2015-07-30 | 60-day | Nate Adcock | |||
| 2015-07-20 | 60-day | Chad Billingsley | |||
| 2015-07-19 | 15-day | Gorkys Hernández | |||
| 2015-07-11 | 60-day | Tyler Anderson | |||
| 2015-07-10 | 15-day | Jeff Baker | |||
| 2015-07-02 | 60-day | Tim Lincecum | |||
| 2015-06-27 | 15-day | Giancarlo Stanton | |||
| 2015-06-24 | 60-day | Corey Hart | |||
| 2015-06-17 | 60-day | Marco Scutaro | |||
| 2015-06-04 | 15-day | Archie Bradley | |||
| 2015-06-01 | 60-day | Jordan Lyles | |||
| 2015-05-30 | 15-day | Brandon Kintzler | |||
| 2015-05-04 | 60-day | Andrew Lambo | Plantar fasciitis in left foot | 2015-05-19 | is on the 15-day disabled list |
| 2015-05-03 | 60-day | Brandon Morrow | Inflammation right shoulder | 2015-05-18 | is on the 15-day disabled list |
| 2015-04-26 | 60-day | Brandon McCarthy | Right elbow surgery | 2015-10-05 | is on the 60-day disabled list and is expected to miss the remainder of the season |
| 2015-04-26 | 60-day | Adam Ottavino | Partially torn right UCL | 2015-10-05 | is on the 15-day disabled list and is expected to miss the remainder of the season |
| 2015-04-20 | 60-day | Jerry Blevins | Fractured left forearm | 2015-07-04 | is on the 15-day disabled list and is expected to miss 2-3 months |
| 2015-04-13 | 60-day | Don Kelly | Broken right ring finger | 2015-05-18 | is on the 15-day disabled list |
| 2015-04-12 | 60-day | Charlie Culberson | Bulging disc in lower back | 2015-06-11 | is on the 60-day disabled list |
| 2015-04-09 | 60-day | Gerald Laird | Lower back spasms | 2015-06-08 | is on the 60-day disabled list |
| 2015-04-06 | 60-day | César Puello | Stress fracture in back | 2015-06-05 | is on the 60-day disabled list |
| 2015-04-06 | 60-day | Josh Outman | Sore left shoulder | 2015-06-05 | is on the 60-day disabled list |
| 2015-04-05 | 60-day | Bronson Arroyo | Right elbow surgery | 2015-06-04 | is on the 60-day disabled list |
| 2015-04-04 | 60-day | Josh Johnson | Right elbow surgery | 2015-05-18 | is on the 15-day disabled list |
| 2015-04-04 | 60-day | Cory Luebke | Left elbow surgery | 2015-06-03 | is on the 60-day disabled list |
| 2015-03-31 | 60-day | Lisalverto Bonilla | Right elbow surgery | 2015-10-05 | is on the 60-day disabled list and will miss the entire season |
| 2015-03-27 | 15-day | Vic Black | Right shoulder tendinitis/herniated disc in neck | 2015-05-18 | is on the 15-day disabled list |
| 2015-03-27 | 15-day | Jim Henderson | Right shoulder inflammation | 2015-05-18 | is on the 15-day disabled list |
| 2015-03-27 | 15-day | Oscar E. Hernandez | Left wrist surgery | 2015-05-18 | is on the 15-day disabled list |
| 2015-03-27 | 60-day | Nate McLouth | Right shoulder surgery | 2015-05-18 | is on the 15-day disabled list |
| 2015-03-27 | 60-day | Brandon Cumpton | Right elbow surgery | 2015-10-05 | is on the 15-day disabled list and will miss the entire season |
| 2015-03-27 | 60-day | Jonathan Pettibone | Right shoulder surgery | 2015-05-26 | is on the 60-day disabled list |
| 2015-03-27 | 60-day | Justin Sellers | Sore left Achilles | 2015-05-18 | is on the 15-day disabled list |
| 2015-03-27 | 60-day | Hyun Jin Ryu | Tightness in left shoulder | 2015-05-26 | is on the 60-day disabled list |
| 2015-03-27 | 60-day | Brandon League | Strained right shoulder | 2015-05-26 | is on the 60-day disabled list |
| 2015-03-27 | 60-day | Jacob Turner | Strained flexor tendon in right forearm | 2015-05-26 | is on the 60-day disabled list |
| 2015-03-26 | 60-day | Tim Federowicz | Right knee surgery | 2015-05-25 | is on the 60-day disabled list |
| 2015-03-16 | 60-day | Cliff Lee | Torn flexor tendon in left forearm | 2015-05-15 | is on the 60-day disabled list |
| 2015-03-01 | 60-day | Tyler Chatwood | Right elbow surgery | 2015-05-18 | is on the 60-day disabled list |
.