| Date | Status | Player | Injury | Target Return? | Prognosis |
|---|---|---|---|---|---|
| 2015-09-29 | 60-day | Raffy Lopez | |||
| 2015-09-06 | 60-day | Cesar Cabral | |||
| 2015-09-05 | 15-day | Hanley Ramírez | |||
| 2015-09-02 | 60-day | Alex Claudio | |||
| 2015-08-27 | 15-day | Desmond Jennings | |||
| 2015-08-26 | 15-day | Curt Casali | |||
| 2015-08-20 | 15-day | Aníbal Sánchez | |||
| 2015-08-15 | 7-day | Steven Wright | |||
| 2015-08-02 | 60-day | Diego Moreno | |||
| 2015-07-31 | 60-day | C.J. Wilson | |||
| 2015-07-08 | 60-day | Nick Hagadone | |||
| 2015-06-19 | 60-day | Sergio Santos | |||
| 2015-06-19 | 60-day | Kyle Blanks | |||
| 2015-06-01 | 15-day | Steve Tolleson | |||
| 2015-05-17 | 15-day | Jordan Schafer | |||
| 2015-05-04 | 15-day | Oswaldo Arcia | Right hip irritation | 2015-05-19 | is on the 15-day disabled list |
| 2015-05-03 | 15-day | Tyler Olson | Bruised right knee | 2015-05-18 | is on the 15-day disabled list |
| 2015-05-01 | 60-day | T.J. House | Left shoulder inflammation | 2015-05-16 | is on the 15-day disabled list |
| 2015-04-22 | 15-day | Ryan Brett | Partially dislocated left shoulder | 2015-05-18 | is on the 15-day disabled list |
| 2015-04-07 | 60-day | Nick Tepesch | Elbow | 2015-06-06 | is on the 60-day disabled list |
| 2015-04-07 | 60-day | Joe Nathan | Right elbow surgery | 2015-10-05 | is on the 60-day disabled list and will miss the remainder of the season |
| 2015-04-05 | 60-day | Yu Darvish | Right elbow surgery | 2015-10-05 | is on the 60-day disabled list and will miss the entire season |
| 2015-04-01 | 15-day | Kyuji Fujikawa | Strained right groin | 2015-05-18 | is on the 15-day disabled list |
| 2015-03-29 | 15-day | Edwin Escobar | Sore left shoulder | 2015-05-18 | is on the 15-day disabled list |
| 2015-03-28 | 60-day | Antoan Richardson | Back surgery | 2015-05-27 | is on the 60-day disabled list |
| 2015-03-27 | 60-day | Maicer Izturis | Strained right groin | 2015-05-26 | is on the 60-day disabled list |
| 2015-03-27 | 60-day | Tyler Skaggs | Left elbow surgery | 2015-05-26 | is on the 60-day disabled list |
| 2015-02-26 | 60-day | Taylor Thompson | Strained right shoulder | 2015-05-18 | is on the 60-day disabled list |
.