| Date | Status | Player | Injury | Target Return? | Prognosis |
|---|
| 2015-02-01 | Probable | Bryan Stork | Knee | | is probable for Super Bowl XLIX Sunday against Seattle |
| 2015-02-01 | Probable | Chris Jones | Elbow | | is probable for Super Bowl XLIX Sunday against Seattle |
| 2015-02-01 | Probable | Richard Sherman | Elbow | | is probable for Super Bowl XLIX Sunday against New England |
| 2015-02-01 | Probable | Justin Britt | Knee | | is probable for Super Bowl XLIX Sunday against New England |
| 2015-02-01 | Probable | Earl Thomas | Shoulder | | is probable for Super Bowl XLIX Sunday against New England |
| 2015-02-01 | Probable | J.R. Sweezy | Ankle | | is probable for Super Bowl XLIX Sunday against New England |
| 2015-02-01 | Probable | Marshawn Lynch | Back | | is probable for Super Bowl XLIX Sunday against New England |
| 2015-02-01 | Probable | Kam Chancellor | Knee | | is probable for Super Bowl XLIX Sunday against New England |
| 2015-02-01 | Probable | Sealver Siliga | Foot | | is probable for Super Bowl XLIX Sunday against Seattle |
| 2015-02-01 | Probable | Tom Brady | Ankle | | is probable for Super Bowl XLIX Sunday against Seattle |
| 2015-02-01 | Probable | Dont'a Hightower | Shoulder | | is probable for Super Bowl XLIX Sunday against Seattle |
| 2015-02-01 | Probable | Akeem Ayers | Knee | | is probable for Super Bowl XLIX Sunday against Seattle |
| 2015-01-12 | Injured-reserve | Paul Richardson | Knee | | is on injured reserve |
| 2015-01-06 | Injured-reserve | Jordan Hill | Calf | | is on injured reserve |
| 2014-12-27 | Injured-reserve | Alfonzo Dennard | Hamstring | | is on injured reserve |
| 2014-12-17 | Injured-reserve | Dominique Easley | Knee | | is on injured reserve |
| 2014-12-04 | Injured-reserve | Aaron Dobson | Hamstring | | is on injured reserve |
| 2014-11-28 | Injured-reserve | Kevin Pierre-Louis | Shoulder | | is on injured reserve |
| 2014-11-12 | Injured-reserve | Zach Miller | Ankle | | is on injured reserve |
| 2014-11-11 | Injured-reserve | Brandon Mebane | Hamstring | | is on injured reserve |
| 2014-11-08 | Injured-reserve | Stephen Schilling | Knee | | is on injured reserve |
| 2014-11-05 | Injured-reserve | Greg Scruggs | Knee | | is on injured reserve |
| 2014-10-25 | Injured-reserve | Derrick Coleman | Foot | | is on injured reserve |
| 2014-10-18 | Injured-reserve | Cassius Marsh | Foot | | is on injured reserve |
| 2014-10-16 | Injured-reserve | Stevan Ridley | Knee | | is on injured reserve |
| 2014-10-16 | Injured-reserve | Jerod Mayo | Knee | | is on injured reserve |
| 2014-10-06 | Injured-reserve | Michael Buchanan | Ankle | | is on injured reserve |
| 2014-09-03 | Injured-reserve | Lemuel Jeanpierre | Neck | | is on injured reserve |
| 2014-08-30 | Injured-reserve | Greg Orton | Achilles | | is on injured reserve |
| 2014-08-30 | Injured-reserve | James Morris | Ankle | | is on injured reserve |
| 2014-08-30 | Injured-reserve | D'Anthony Smith | Biceps | | is on injured reserve |
| 2014-08-26 | Injured-reserve | Tyler Gaffney | Knee | | is on injured reserve |
| 2014-08-26 | Injured-reserve | A.J. Jefferson | Ankle | | is on injured reserve |
| 2014-08-26 | Injured-reserve | Cameron Gordon | Undisclosed | | is on injured reserve |
| 2014-08-26 | Injured-reserve | Heath Farwell | Groin | | is on injured reserve |
| 2014-08-26 | Injured-reserve | C.J. Davis | Undisclosed | | is on injured reserve |
| 2014-08-26 | Out | Eric Pinkins | Foot | | is on the non-football injury list |
| 2014-08-01 | Injured-reserve | Jesse Williams | Knee | | is on injured reserve |
| 2014-07-31 | Injured-reserve | Anthony McCoy | Achilles | | is on injured reserve |
| 2014-07-29 | Injured-reserve | Taylor Price | Undisclosed | | is on injured reserve |
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