| Red Sox 6 Astros 3 - Final |
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| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | Tot |
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| Hou | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 3 |
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| Bos | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 3 | x | 6 |
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Houston at Boston - Mon 16-May-2022 |
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| Astros Pitchers | IP | BF | H | HR | K | BB | IBB | HB | ER | Win | Sav | WHIP | ERA | BABIP | FIP | kwERA |
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| Jake Odorizzi | | 5.00 | 19 | 3 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 0 | 0.800 | 1.80 | .214 | 2.10 | 3.51 |
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| Phil Maton | | 2.00 | 8 | 2 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1.000 | 4.50 | .200 | 10.10 | 5.40 |
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| Héctor Neris | | 1.00 | 7 | 3 | 1 | 1 | 1 | 0 | 0 | 3 | 0 | 0 | 4.000 | 27.00 | .500 | 17.10 | 5.40 |
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| Total | 8.00 | 34 | 8 | 2 | 6 | 2 | 0 | 1 | 5 | 0 | 0 | 1.250 | 5.62 | .261 | 5.97 | 4.34 |
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| Red Sox Pitchers | IP | BF | H | HR | K | BB | IBB | HB | ER | Win | Sav | WHIP | ERA | BABIP | FIP | kwERA |
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| Garrett Whitlock | | 5.00 | 21 | 3 | 1 | 3 | 2 | 0 | 1 | 2 | 0 | 0 | 1.000 | 3.60 | .143 | 6.30 | 5.40 |
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| Jake Diekman | | 0.67 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.500 | 0.00 | .000 | 7.60 | 9.40 |
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| John Schreiber | | 0.33 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.000 | 0.00 | .000 | -2.90 | -6.60 |
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| Matt Barnes | | 0.33 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 6.000 | 27.00 | .667 | 3.10 | 5.40 |
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| Matt Strahm | | 1.67 | 7 | 1 | 0 | 3 | 0 | 0 | 1 | 0 | 1 | 0 | 0.600 | 0.00 | .333 | 1.30 | 1.97 |
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| Hansel Robles | | 1.00 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.000 | 0.00 | .333 | 3.10 | 5.40 |
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| Total | 9.00 | 38 | 7 | 1 | 7 | 3 | 0 | 2 | 3 | 1 | 1 | 1.111 | 3.00 | .240 | 4.66 | 4.77 |
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