| Astros 4 Mariners 0 - Final |
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| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | Tot |
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| Hou | 0 | 1 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 4 |
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| Sea | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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Houston at Seattle - Sat 16-Apr-2022 |
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| Astros Pitchers | IP | BF | H | HR | K | BB | IBB | HB | ER | Win | Sav | WHIP | ERA | BABIP | FIP | kwERA |
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| Justin Verlander | | 8.00 | 27 | 3 | 0 | 8 | 0 | 0 | 1 | 0 | 1 | 0 | 0.375 | 0.00 | .167 | 1.48 | 2.29 |
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| Héctor Neris | | 1.00 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.000 | 0.00 | .000 | 1.10 | 1.40 |
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| Total | 9.00 | 30 | 3 | 0 | 9 | 0 | 0 | 1 | 0 | 1 | 0 | 0.333 | 0.00 | .150 | 1.43 | 2.20 |
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| Mariners Pitchers | IP | BF | H | HR | K | BB | IBB | HB | ER | Win | Sav | WHIP | ERA | BABIP | FIP | kwERA |
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| Chris Flexen | | 6.00 | 24 | 5 | 1 | 3 | 1 | 0 | 0 | 3 | 0 | 0 | 1.000 | 4.50 | .211 | 4.77 | 4.40 |
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| Matt Festa | | 0.33 | 4 | 2 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 9.000 | 27.00 | 1.000 | 6.10 | 5.40 |
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| Justus Sheffield | | 0.67 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.500 | 0.00 | .000 | 7.60 | 9.40 |
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| Erik Swanson | | 2.00 | 7 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0.500 | 0.00 | .250 | 0.10 | 0.26 |
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| Total | 9.00 | 38 | 8 | 1 | 7 | 3 | 0 | 0 | 4 | 0 | 0 | 1.222 | 4.00 | .259 | 3.99 | 4.14 |
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